Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom

S. T. McCain, M. E. Gehm, Y. Wang, N. P. Pitsianis, D. J. Brady

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r 2 > 0.98. Leave-one-out cross-validation demonstrates prediction errors of <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.

Original languageEnglish (US)
Pages (from-to)663-671
Number of pages9
JournalApplied Spectroscopy
Volume60
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Chemometrics
  • Multiplexing
  • Raman spectroscopy

ASJC Scopus subject areas

  • Instrumentation
  • Spectroscopy

Fingerprint

Dive into the research topics of 'Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom'. Together they form a unique fingerprint.

Cite this