Cocaine self-administration and naltrindole, a delta-selective opioid antagonist

Larry D. Reid, Stanley D. Glick, Kent A. Menkens, Edward D. French, Edward J. Bilsky, Frank Porreca

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Recent reports from several laboratories have suggested a role for delta opioid receptors in expressing some of the biochemical and behavioral effects of cocaine. Here, this possibility has been further explored by evaluating the propensity of rats to self-administer i.v. cocaine in the absence or presence of naltrindole, a selective delta opioid antagonist. Following a number of days of stable cocaine intake, and before a day’s session, naltrindole (3 or 10 mg kg-1) reduced pressing for cocaine, regardless of the schedule of reinforcement. These data further support the role of processes associated with delta opioid receptors in the ability of cocaine to reinforce its own use.

Original languageEnglish (US)
Pages (from-to)1409-1412
Number of pages4
Issue number10
StatePublished - Jul 1995


  • Cocaine
  • Delta opioid receptors
  • Naltrindole
  • Opioids
  • Rats
  • Reinforcement
  • Reward
  • Self-administration

ASJC Scopus subject areas

  • Neuroscience(all)


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