Cocaine immunotoxicity: abnormal cytokine production in hispanic drug users

Chen Guan-Jie; Radhakrishna Pillai; Julie R. Erickson; Francisca Martinez; Antonio L. Estrada; Ronald Ross Watson

doi:10.1016/0378-4274(91)90058-E

Cocaine immunotoxicity: abnormal cytokine production in hispanic drug users

Chen Guan-Jie, Radhakrishna Pillai, Julie R. Erickson, Francisca Martinez, Antonio L. Estrada, Ronald Ross Watson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Peripheral blood lymphocytes from 47 Hispanic poly-drug users with a history of cocaine abuse were analyzed for in vitro production of interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (IFN) and plasma levels of soluble IL-2 receptor (SIL-2R). Cocaine use was confirmed and quantified by analysis of hair and urine samples, and subjects were grouped into 3 based on the extent of cocaine metabolites detected. No significant differences in IL-1 and IFN production were seen between the 3 groups. However, subjects with higher levels of cocaine in hair also showed higher levels of IL-2. In addition, a positive correlation was seen between cocaine concentrations and IL-2 levels. A corresponding negative correlation was seen between cocaine levels and levels of plasma SIL-2R. These findings suggest modulation of the IL-2 network by cocaine in poly-drug users.

Original language	English (US)
Pages (from-to)	81-88
Number of pages	8
Journal	Toxicology letters
Volume	59
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-4274(91)90058-E
State	Published - Dec 1991

Keywords

Cocaine
Gamma-interferon
Immunodeficiency
Interleukin-1
Interleukin-2
Soluble interleukin-2 receptor

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(91)90058-E

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@article{9f99f314cc4f4ccba20770318a5b5330,

title = "Cocaine immunotoxicity: abnormal cytokine production in hispanic drug users",

abstract = "Peripheral blood lymphocytes from 47 Hispanic poly-drug users with a history of cocaine abuse were analyzed for in vitro production of interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (IFN) and plasma levels of soluble IL-2 receptor (SIL-2R). Cocaine use was confirmed and quantified by analysis of hair and urine samples, and subjects were grouped into 3 based on the extent of cocaine metabolites detected. No significant differences in IL-1 and IFN production were seen between the 3 groups. However, subjects with higher levels of cocaine in hair also showed higher levels of IL-2. In addition, a positive correlation was seen between cocaine concentrations and IL-2 levels. A corresponding negative correlation was seen between cocaine levels and levels of plasma SIL-2R. These findings suggest modulation of the IL-2 network by cocaine in poly-drug users.",

keywords = "Cocaine, Gamma-interferon, Immunodeficiency, Interleukin-1, Interleukin-2, Soluble interleukin-2 receptor",

author = "Chen Guan-Jie and Radhakrishna Pillai and Erickson, {Julie R.} and Francisca Martinez and Estrada, {Antonio L.} and Watson, {Ronald Ross}",

note = "Funding Information: The authors are grateful to Rigoberto Centeno, MD and Gloria Venezuelaf or subjectr ecruitmenta nd interview.T his work was supportedi n part by NIDA Grant No. R18 DA 05748,N IH Grant No. DA 04827a nd a minority (Hispanic)p ostdoc-toral study (as part of the NIAAA SpecializedA lcohol ResearchC enter,A A08037).",

year = "1991",

month = dec,

doi = "10.1016/0378-4274(91)90058-E",

language = "English (US)",

volume = "59",

pages = "81--88",

journal = "Toxicology letters",

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publisher = "Elsevier Ireland Ltd",

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TY - JOUR

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T2 - abnormal cytokine production in hispanic drug users

AU - Guan-Jie, Chen

AU - Pillai, Radhakrishna

AU - Erickson, Julie R.

AU - Martinez, Francisca

AU - Estrada, Antonio L.

AU - Watson, Ronald Ross

N1 - Funding Information: The authors are grateful to Rigoberto Centeno, MD and Gloria Venezuelaf or subjectr ecruitmenta nd interview.T his work was supportedi n part by NIDA Grant No. R18 DA 05748,N IH Grant No. DA 04827a nd a minority (Hispanic)p ostdoc-toral study (as part of the NIAAA SpecializedA lcohol ResearchC enter,A A08037).

PY - 1991/12

Y1 - 1991/12

N2 - Peripheral blood lymphocytes from 47 Hispanic poly-drug users with a history of cocaine abuse were analyzed for in vitro production of interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (IFN) and plasma levels of soluble IL-2 receptor (SIL-2R). Cocaine use was confirmed and quantified by analysis of hair and urine samples, and subjects were grouped into 3 based on the extent of cocaine metabolites detected. No significant differences in IL-1 and IFN production were seen between the 3 groups. However, subjects with higher levels of cocaine in hair also showed higher levels of IL-2. In addition, a positive correlation was seen between cocaine concentrations and IL-2 levels. A corresponding negative correlation was seen between cocaine levels and levels of plasma SIL-2R. These findings suggest modulation of the IL-2 network by cocaine in poly-drug users.

AB - Peripheral blood lymphocytes from 47 Hispanic poly-drug users with a history of cocaine abuse were analyzed for in vitro production of interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (IFN) and plasma levels of soluble IL-2 receptor (SIL-2R). Cocaine use was confirmed and quantified by analysis of hair and urine samples, and subjects were grouped into 3 based on the extent of cocaine metabolites detected. No significant differences in IL-1 and IFN production were seen between the 3 groups. However, subjects with higher levels of cocaine in hair also showed higher levels of IL-2. In addition, a positive correlation was seen between cocaine concentrations and IL-2 levels. A corresponding negative correlation was seen between cocaine levels and levels of plasma SIL-2R. These findings suggest modulation of the IL-2 network by cocaine in poly-drug users.

KW - Cocaine

KW - Gamma-interferon

KW - Immunodeficiency

KW - Interleukin-1

KW - Interleukin-2

KW - Soluble interleukin-2 receptor

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Cocaine immunotoxicity: abnormal cytokine production in hispanic drug users

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Keywords

ASJC Scopus subject areas

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