Cluster analysis of the codon use frequency of MHC genes from different species

Jianmin Ma, Tong Zhou, Wanjun Gu, Xiao Sun, Zuhong Lu

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The relative synonymous codon use frequency of 135 MHC genes from four mammal species (Homo sapiens, Pan troglodyte, Macaca mulanta and Rattus norvegicus) is analyzed using a hierarchical cluster method. The result suggests that gene function is the dominant factor that determines codon usage bias, while species is a minor factor that determines further difference in codon usage bias for genes with similar functions. The conclusion may be useful in gene classification and gene function prediction.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
Issue number2-3
StatePublished - 2002
Externally publishedYes


  • Codon usage bias
  • Hierarchical cluster analysis
  • MHC
  • Relative synonymous codon use frequency (RSCU)

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • Applied Mathematics


Dive into the research topics of 'Cluster analysis of the codon use frequency of MHC genes from different species'. Together they form a unique fingerprint.

Cite this