CLTP and LCAT activity in postmenopausal women

The ami of this study was to compare cholesterol ester transfer protein (CETP) and lecithin cholesterol acyltransferase 11.(A I') activities in postmenopausal women not undergoing hormone replacement therapy (noHRT) vs. women undergoing estrogen lephicemem therapy (FRT) or a combined HRT (cHRT). Ie; postmenopausal women 55-70 years of age participated m the study CI-TP und LCAT activities were measured by decreases in the mass of endogenous unesterified cholesterol in incubated plasma samples. Mean total cholesterol (255 ± 38. 213 ± 31 and 261 ±39), HDL cholesterol ((SO t. 11.61 ± 11.59-t 23 ) and total/HDL ratios (4.3 ± 0.5, 3.7±11.51 ±11.51 ± 25) were not different among groups (noHRT, FRT. cHRT. respectn-elv i No differences were found m either ( I TP or LCAT activities among groups, however there was a trend for CL'I P activity to lie higher in the two groups undergoing HRT Mean CETP activities for noHRT, FR1. and cHRT were 15 8, 34 6, 54.3 ninol ml-hr. respectively Mean LCAT activities for the three groups were 62 6, 69.2. 56 7 nmol/ml-hr. respectively This study .suggests that hormone replacement therapy may not affect reverse cholesterol transport bv i CAT and CFTP mediated mechanisms.