Clostridium difficile infection an overview of the disease and its pathogenesis, epidemiology and interventions

V. K. Viswanathan; M. J. Mallozzi; Gayatri Vedantam

doi:10.4161/gmic.1.4.12706

Clostridium difficile infection an overview of the disease and its pathogenesis, epidemiology and interventions

Research output: Contribution to journal › Article › peer-review

Abstract

Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.

Original language	English (US)
Pages (from-to)	234-242
Number of pages	9
Journal	Gut microbes
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/gmic.1.4.12706
State	Published - 2010

Keywords

CDAD
CDI
Clostridium difficile
Hypervirulent
Infection
Infection control
Pathogenesis
Spore

ASJC Scopus subject areas

Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases

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10.4161/gmic.1.4.12706

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abstract = "Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.",

keywords = "CDAD, CDI, Clostridium difficile, Hypervirulent, Infection, Infection control, Pathogenesis, Spore",

author = "Viswanathan, \{V. K.\} and Mallozzi, \{M. J.\} and Gayatri Vedantam",

note = "Funding Information: We thank Drs. Dale Gerding, Stuart Johnson, Farida Siddiqui, Glenn Tillotson, Glenn Songer and Neil Ampel for helpful discussions and collaboration. This work was supported by grants from the US Department of Veterans Affairs (Gayatri Vedantam) and the University of Arizona (Gayatri Vedantam and V.K. Viswanathan).",

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doi = "10.4161/gmic.1.4.12706",

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PY - 2010

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AB - Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.

KW - CDAD

KW - CDI

KW - Clostridium difficile

KW - Hypervirulent

KW - Infection

KW - Infection control

KW - Pathogenesis

KW - Spore

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Clostridium difficile infection an overview of the disease and its pathogenesis, epidemiology and interventions

Abstract

Keywords

ASJC Scopus subject areas

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