Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp

Nathan A. Ellis; Tian Zhang Ye; Susan Patton; James German; Peter N. Goodfellow; Polly Weller

doi:10.1038/ng0494-394

Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp

Nathan A. Ellis, Tian Zhang Ye, Susan Patton, James German, Peter N. Goodfellow, Polly Weller

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Abstract

The pseudoautosomal boundaries are the interface between pseudoautosomal and sex chromosome−specific DNA sequences. We have isolated a gene, PBDX, from the human pseudoautosomal boundary region of Xp. The three exons at the 5' end of PBDX are situated in the pseudoautosomal region immediately downstream of MIC2, whereas the other seven exons are in the X−speciflc region. Hence, PBDX is inherited in two modes: its 5' end is pseudoautosomally inherited and its 3' end is X−linked. The predicted amino acid sequence of the 540 bp coding region is 48% homologous to 12E7, the product of MIC2. By virtue of its position, PBDX becomes an excellent candidate for the XG blood group gene.

Original language	English (US)
Pages (from-to)	394-400
Number of pages	7
Journal	Nature Genetics
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/ng0494-394
State	Published - Apr 1994
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp",

abstract = "The pseudoautosomal boundaries are the interface between pseudoautosomal and sex chromosome−specific DNA sequences. We have isolated a gene, PBDX, from the human pseudoautosomal boundary region of Xp. The three exons at the 5' end of PBDX are situated in the pseudoautosomal region immediately downstream of MIC2, whereas the other seven exons are in the X−speciflc region. Hence, PBDX is inherited in two modes: its 5' end is pseudoautosomally inherited and its 3' end is X−linked. The predicted amino acid sequence of the 540 bp coding region is 48% homologous to 12E7, the product of MIC2. By virtue of its position, PBDX becomes an excellent candidate for the XG blood group gene.",

author = "Ellis, {Nathan A.} and Ye, {Tian Zhang} and Susan Patton and James German and Goodfellow, {Peter N.} and Polly Weller",

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T1 - Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp

AU - Ellis, Nathan A.

AU - Ye, Tian Zhang

AU - Patton, Susan

AU - German, James

AU - Goodfellow, Peter N.

AU - Weller, Polly

PY - 1994/4

Y1 - 1994/4

N2 - The pseudoautosomal boundaries are the interface between pseudoautosomal and sex chromosome−specific DNA sequences. We have isolated a gene, PBDX, from the human pseudoautosomal boundary region of Xp. The three exons at the 5' end of PBDX are situated in the pseudoautosomal region immediately downstream of MIC2, whereas the other seven exons are in the X−speciflc region. Hence, PBDX is inherited in two modes: its 5' end is pseudoautosomally inherited and its 3' end is X−linked. The predicted amino acid sequence of the 540 bp coding region is 48% homologous to 12E7, the product of MIC2. By virtue of its position, PBDX becomes an excellent candidate for the XG blood group gene.

AB - The pseudoautosomal boundaries are the interface between pseudoautosomal and sex chromosome−specific DNA sequences. We have isolated a gene, PBDX, from the human pseudoautosomal boundary region of Xp. The three exons at the 5' end of PBDX are situated in the pseudoautosomal region immediately downstream of MIC2, whereas the other seven exons are in the X−speciflc region. Hence, PBDX is inherited in two modes: its 5' end is pseudoautosomally inherited and its 3' end is X−linked. The predicted amino acid sequence of the 540 bp coding region is 48% homologous to 12E7, the product of MIC2. By virtue of its position, PBDX becomes an excellent candidate for the XG blood group gene.

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Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp

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