TY - JOUR
T1 - Clonidine in neuropsychiatric disorders
T2 - A review
AU - Sandyk, Reuven
AU - Gillman, Mark A.
AU - Iacono, Robert P.
AU - Bamford, Colin R.
PY - 1987
Y1 - 1987
N2 - We describe the basic pharmacological principles underlying the activity of the alpha2-adrenergic receptor agonist clonidine, including its interactions with the cholinergic, histaminergic, serotoninergic, endorphinergic and possibly dopaminergic systems. The use of clonidine for the therapy of various neuropsychiatric indications in which it appears to be beneficial is described. These conditions include migraine, Korsakoff's psychosis, Tourette's syndrome, withdrawal states, tardive dyskinesia, essential tremor, neuroleptic-induced akathisia, neurogenic bladder, idiopathic orthostatic hypotension, paroxysmal localised hyperhydrosis, diabetic neuropathy and stiff-man syndrome. The need for long term evaluation of this agent in some of these diseases is stressed.
AB - We describe the basic pharmacological principles underlying the activity of the alpha2-adrenergic receptor agonist clonidine, including its interactions with the cholinergic, histaminergic, serotoninergic, endorphinergic and possibly dopaminergic systems. The use of clonidine for the therapy of various neuropsychiatric indications in which it appears to be beneficial is described. These conditions include migraine, Korsakoff's psychosis, Tourette's syndrome, withdrawal states, tardive dyskinesia, essential tremor, neuroleptic-induced akathisia, neurogenic bladder, idiopathic orthostatic hypotension, paroxysmal localised hyperhydrosis, diabetic neuropathy and stiff-man syndrome. The need for long term evaluation of this agent in some of these diseases is stressed.
KW - Clonidine
KW - Neuropsychiatric disorders
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U2 - 10.3109/00207458708987129
DO - 10.3109/00207458708987129
M3 - Review article
C2 - 3308732
AN - SCOPUS:0023394520
SN - 0020-7454
VL - 35
SP - 205
EP - 215
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 3-4
ER -