TY - JOUR
T1 - Clinically related behavioral models
T2 - Bone cancer pain
AU - Sabino, Mary Ann C.
AU - Mantyh, Patrick W.
PY - 2004/11
Y1 - 2004/11
N2 - The most common cancers such as breast, prostate and lung cancers have a strong predilection to metastasize to bone. Bone metastasis frequently results in pain, pathologic fractures, hypercalcemia and spinal cord compression. Pain can have a devastating effect on the quality of life in advanced cancer patients and is a serious complication of cancer. An animal model of bone cancer pain was developed that mimics the radiologic, behavioral and histologic parameters that define lytic bone cancer pain. By confining tumor cells within bone, direct effects of cancer cells on the development of bone cancer pain might be elucidated. Chemicals derived from tumor cells, inflammatory cells and cells derived from bone appear to be simultaneously involved in driving this pain state, which is frequently difficult to control. Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve our ability to provide mechanism-based treatments therapies and improve the quality of life of cancer patients.
AB - The most common cancers such as breast, prostate and lung cancers have a strong predilection to metastasize to bone. Bone metastasis frequently results in pain, pathologic fractures, hypercalcemia and spinal cord compression. Pain can have a devastating effect on the quality of life in advanced cancer patients and is a serious complication of cancer. An animal model of bone cancer pain was developed that mimics the radiologic, behavioral and histologic parameters that define lytic bone cancer pain. By confining tumor cells within bone, direct effects of cancer cells on the development of bone cancer pain might be elucidated. Chemicals derived from tumor cells, inflammatory cells and cells derived from bone appear to be simultaneously involved in driving this pain state, which is frequently difficult to control. Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve our ability to provide mechanism-based treatments therapies and improve the quality of life of cancer patients.
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U2 - 10.1016/j.ddmod.2004.09.007
DO - 10.1016/j.ddmod.2004.09.007
M3 - Review article
AN - SCOPUS:23744464365
VL - 1
SP - 127
EP - 134
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
SN - 1740-6757
IS - 2
ER -