Clinically related behavioral models: Bone cancer pain

Mary Ann C. Sabino, Patrick W. Mantyh

Research output: Contribution to journalReview articlepeer-review


The most common cancers such as breast, prostate and lung cancers have a strong predilection to metastasize to bone. Bone metastasis frequently results in pain, pathologic fractures, hypercalcemia and spinal cord compression. Pain can have a devastating effect on the quality of life in advanced cancer patients and is a serious complication of cancer. An animal model of bone cancer pain was developed that mimics the radiologic, behavioral and histologic parameters that define lytic bone cancer pain. By confining tumor cells within bone, direct effects of cancer cells on the development of bone cancer pain might be elucidated. Chemicals derived from tumor cells, inflammatory cells and cells derived from bone appear to be simultaneously involved in driving this pain state, which is frequently difficult to control. Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve our ability to provide mechanism-based treatments therapies and improve the quality of life of cancer patients.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalDrug Discovery Today: Disease Models
Issue number2
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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