Clinically accessible cell signaling: Second messengers in sepsis and trauma

Thomas F. Rehring, Elizabeth C. Brew, Randall S. Friese, Anirban Banerjee, Alden H. Harken

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Inflammatory mediators of trauma and sepsis transduce cellular events through cell surface receptors initiating intricate membrane and cytosolic reaction cascades that funnel through surprisingly few checkpoints in order to provoke a cellular response. As critical care surgeons, we can explore these cell signaling systems. The purpose of this article is to delineate the six known second messenger pathways relevant to surgical sepsis and trauma. Our comprehension of these signaling systems may offer us an opportunity to blunt post-traumatic cellular injury and promote a constructive response.

Original languageEnglish (US)
Pages (from-to)270-277
Number of pages8
JournalJournal of Surgical Research
Issue number1
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Surgery


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