Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry

Kevin S. Shah, Adriana E. Reyes-Miranda, Steven M. Bradley, Khadijah Breathett, Sandeep R. Das, Ty J. Gluckman, Divya Gupta, Daniel T. Leung, R. Kannan Mutharasan, Pamela N. Peterson, Emily S. Spivak, Rashmee U. Shah

Research output: Contribution to journalArticlepeer-review

Abstract

As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hospitalized with COVID-19 at centers participating in the American Heart Association’s COVID-19 CVD Registry. The primary outcome was odds of enrollment in a clinical trial, according to sex, race, and ethnicity. Among 14,397 adults hospitalized with COVID-19, 9.5% (n = 1,377) were enrolled in a clinical trial. The proportion of enrolled patients was the lowest for Black patients (8%); in multivariable analysis, female and Black patients were less likely to be enrolled in a clinical trial related to COVID-19 compared to men and other racial groups, respectively. Determination of specific reasons for the disparities in trial participation related to COVID-19 in these populations should be further investigated.

Original languageEnglish (US)
JournalJournal of Racial and Ethnic Health Disparities
DOIs
StateAccepted/In press - 2022

Keywords

  • COVID-19
  • Disparities
  • Ethnicity
  • Race

ASJC Scopus subject areas

  • Health(social science)
  • Anthropology
  • Sociology and Political Science
  • Health Policy
  • Public Health, Environmental and Occupational Health

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