Clinical results with acridine orange using a novel confocal laparoscope

Anthony A. Tanbakuchi, Andrew R. Rouse, Kenneth D. Hatch, Arthur F. Gmitro

Research output: Contribution to journalConference articlepeer-review


We previously reported on the development of a multi-spectral confocal laparoscope for clinical imaging. In this paper we present current results using the system to image ovaries with a new laparoscope design using the contrast agent acridine orange. This new laparoscope integrates computer controlled systems for focus, depth scans, and localized contrast agent delivery. Precise axial position control is accomplished with tiny stepper motors integrated inside the laparoscope handle. Ergonomic handle controls allow for data acquisition, deliver of contrast agents, and adjustment of imaging depth during procedures by the surgeon. We have approval to use acridine orange in our clinical trials to image ovaries in vivo during oophorectomies. We present in vivo results using both acridine orange and fluorescein as the topically administered contrast agent.

Original languageEnglish (US)
Article number71720H
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2009
EventEndoscopic Microscopy IV - San Jose, CA, United States
Duration: Jan 25 2009Jan 26 2009


  • Acridine orange
  • Clinical trials
  • Confocal
  • Endoscope
  • Fluorescein
  • Laparoscope
  • Microscopy
  • Ovarian cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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