Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update

Jason H. Karnes; Allan E. Rettie; Andrew A. Somogyi; Rachel Huddart; Alison E. Fohner; Christine M. Formea; Ming Ta Michael Lee; Adrian Llerena; Michelle Whirl-Carrillo; Teri E. Klein; Elizabeth J. Phillips; Scott Mintzer; Andrea Gaedigk; Kelly E. Caudle; John T. Callaghan

doi:10.1002/cpt.2008

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update

Jason H. Karnes, Allan E. Rettie, Andrew A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, Adrian Llerena, Michelle Whirl-Carrillo, Teri E. Klein, Elizabeth J. Phillips, Scott Mintzer, Andrea Gaedigk, Kelly E. Caudle, John T. Callaghan

Research output: Contribution to journal › Review article › peer-review

114 Scopus citations

Abstract

Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis in response to phenytoin treatment. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for the use of phenytoin based on CYP2C9 and/or HLA-B genotypes (updates on cpicpgx.org).

Original language	English (US)
Pages (from-to)	302-309
Number of pages	8
Journal	Clinical Pharmacology and Therapeutics
Volume	109
Issue number	2
DOIs	https://doi.org/10.1002/cpt.2008
State	Published - Feb 2021

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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Karnes, J. H., Rettie, A. E., Somogyi, A. A., Huddart, R., Fohner, A. E., Formea, C. M., Ta Michael Lee, M., Llerena, A., Whirl-Carrillo, M., Klein, T. E., Phillips, E. J., Mintzer, S., Gaedigk, A., Caudle, K. E., & Callaghan, J. T. (2021). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update. Clinical Pharmacology and Therapeutics, 109(2), 302-309. https://doi.org/10.1002/cpt.2008

Karnes, JH, Rettie, AE, Somogyi, AA, Huddart, R, Fohner, AE, Formea, CM, Ta Michael Lee, M, Llerena, A, Whirl-Carrillo, M, Klein, TE, Phillips, EJ, Mintzer, S, Gaedigk, A, Caudle, KE & Callaghan, JT 2021, 'Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update', Clinical Pharmacology and Therapeutics, vol. 109, no. 2, pp. 302-309. https://doi.org/10.1002/cpt.2008

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abstract = "Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis in response to phenytoin treatment. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for the use of phenytoin based on CYP2C9 and/or HLA-B genotypes (updates on cpicpgx.org).",

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update

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