Clinical outcomes in patients on preinjury ibuprofen with traumatic brain injury

Bardiya Zangbar, Viraj Pandit, Peter Rhee, Mazhar Khalil, Narong Kulvatunyou, Terence O'Keeffe, Andrew Tang, Lynn Gries, Donald J. Green, Randall S. Friese, Bellal Joseph

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background The aim of our study was to evaluate the clinical outcomes in patients on preinjury Ibuprofen with traumatic brain injury. Methods We performed a 2-year analysis of all patients on prehospital Ibuprofen with traumatic brain injury and intracranial hemorrhage. Patients on preinjury Ibuprofen were matched using propensity score matching to patients not on Ibuprofen in a 1:2 ratio for age, Glasgow Coma Scale, head-abbreviated injury scale, injury severity score, International Normalized Ratio, and neurologic examination. Outcome measures were progression on repeat head computed tomography (RHCT) and neurosurgical intervention. Results A total of 195 matched (Ibuprofen 65, no-Ibuprofen 130) patients were included. There was no difference in the progression on RHCT (Ibuprofen 18% vs no-Ibuprofen 24%; P =.50). The neurosurgical intervention rate was 18.9% (n = 37). There was no difference for need for neurosurgical intervention (26% vs 16%; P =.10) between the 2 groups. Conclusions In a matched cohort of trauma patients, preinjury Ibuprofen use was not associated with progression of initial intracranial hemorrhage and the need for neurosurgical intervention. Preinjury use of Ibuprofen as an independent variable should not warrant the need for a routine RHCT scan.

Original languageEnglish (US)
Pages (from-to)921-926
Number of pages6
JournalAmerican journal of surgery
Issue number6
StatePublished - Jun 1 2015


  • Ibuprofen
  • Motrin
  • Neurosurgical Intervention
  • Nonsteroidal anti-inflammatory drugs
  • Repeat head computed tomography
  • Traumatic brain injury

ASJC Scopus subject areas

  • Surgery


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