Clinical Implications of Current Findings in Neurodevelopment

Penelope Knapp, Ann M. Mastergeorge

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Research in the last decade has advanced our knowledge about biological factors underlying neurodevelopmental processes in childhood. Genetic research has gone beyond mapping the human genome to identifying epigenetic factors and explicating gene-environment interactions. Biological markers of vulnerability to specific disorders have been identified. The functions of and interactions between neuroanatomic regions have been illuminated by new imaging and other noninvasive techniques, such as EEG, event-related potentials, and functional magnetic resonance imaging, that allow us to link earliest signs of disorders to neurological changes. This article provides an overview of current findings in neurodevelopment, and discusses diagnostic factors, prevention and intervention, and clinical implications.

Original languageEnglish (US)
Pages (from-to)177-197
Number of pages21
JournalPsychiatric Clinics of North America
Issue number1
StatePublished - Mar 2009
Externally publishedYes


  • Biological factors
  • Developmental trajectories
  • Early indicators
  • Neurodevelopment
  • Neuroplasticity

ASJC Scopus subject areas

  • Psychiatry and Mental health


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