TY - JOUR
T1 - Clinical and Molecular Characteristics and Burden of Kidney Cancer Among Hispanics and Native Americans
T2 - Steps Toward Precision Medicine
AU - Batai, Ken
AU - Bergersen, Andrew
AU - Price, Elinora
AU - Hynes, Kieran
AU - Ellis, Nathan A.
AU - Lee, Benjamin R.
N1 - Funding Information:
Supported in part by Institutional Research Grant IRG-16-124-37-IRG from the American Cancer Society. We would like to acknowledge the individuals affected by cancer represented in our data. We are grateful for editorial assistance from Melissa McCormick, MA.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/6
Y1 - 2018/6
N2 - Cancer disparities in Native Americans (NAs) and Hispanic Americans (HAs) vary significantly in terms of cancer incidence and mortality rates across geographic regions. This review reports that kidney and renal pelvis cancers are unevenly affecting HAs and NAs compared to European Americans of non-Hispanic origin, and that currently there is significant need for improved data and reporting to be able to advance toward genomic-based precision medicine for the assessment of such cancers in these medically underserved populations. More specifically, in states along the US-Mexico border, HAs and NAs have higher kidney cancer incidence rates as well as a higher prevalence of kidney cancer risk factors, including obesity and chronic kidney disease. They are also more likely to receive suboptimal care compared to European Americans. Furthermore, they are underrepresented in epidemiologic, clinical, and molecular genomic studies of kidney cancer. Therefore, we maintain that progress in precision medicine for kidney cancer care requires an understanding of various factors among HAs and NAs, including the real kidney cancer burden, variations in clinical care, issues related to access to care, and specific clinical and molecular characteristics.
AB - Cancer disparities in Native Americans (NAs) and Hispanic Americans (HAs) vary significantly in terms of cancer incidence and mortality rates across geographic regions. This review reports that kidney and renal pelvis cancers are unevenly affecting HAs and NAs compared to European Americans of non-Hispanic origin, and that currently there is significant need for improved data and reporting to be able to advance toward genomic-based precision medicine for the assessment of such cancers in these medically underserved populations. More specifically, in states along the US-Mexico border, HAs and NAs have higher kidney cancer incidence rates as well as a higher prevalence of kidney cancer risk factors, including obesity and chronic kidney disease. They are also more likely to receive suboptimal care compared to European Americans. Furthermore, they are underrepresented in epidemiologic, clinical, and molecular genomic studies of kidney cancer. Therefore, we maintain that progress in precision medicine for kidney cancer care requires an understanding of various factors among HAs and NAs, including the real kidney cancer burden, variations in clinical care, issues related to access to care, and specific clinical and molecular characteristics.
KW - American Indians
KW - Cancer health disparities
KW - Health disparities
KW - Latinos
KW - Renal-cell carcinoma
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U2 - 10.1016/j.clgc.2018.01.006
DO - 10.1016/j.clgc.2018.01.006
M3 - Comment/debate
C2 - 29449090
AN - SCOPUS:85047347710
VL - 16
SP - e535-e541
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
SN - 1558-7673
IS - 3
ER -