In the present report two distinct but aligned areas of investigation pursued in this and other laboratories are reviewed. In the first, the experimental production of hctero-, iso-, and autoantibodies to prostatic and other accessory glands tissues of reproduction of man, monkey, canine, and rabbit have been employed to study the immunologic properties of these tissues and their possible immunopathogenicity as related to diseases of the prostate in man. In the second, the results of the experimental aspects of prostatic cryosurgery leading to the successful adaptation of the therapeutic utilization of cryosurgery for the destruction of benign and malignant prostatic tissue, particularly in the treatment of the elderly and in cases presently not amenable to the conventional methods of prostatic surgery, are presented. The possible production of an ‘immuno-cryothermic’ response to freezing and refreezing the primary prostatic tumour in cases of metastasizing adenocarcinoma of the prostate as observed by the remission of metastatic lesions in six patients so treated, possibly presents an entirely new approach to the treatment of malignant diseases through the in situ immunization of the host to his own tumour.
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