"Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Jun Wang; Mahesh Uttamchandani; Junqi Li; Mingyu Hu; Shao Q. Yao

doi:10.1039/b609446e

"Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Jun Wang, Mahesh Uttamchandani, Junqi Li, Mingyu Hu, Shao Q. Yao

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.

Original language	English (US)
Pages (from-to)	3783-3785
Number of pages	3
Journal	Chemical Communications
Issue number	36
DOIs	https://doi.org/10.1039/b609446e
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b609446e

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title = "{"}Click{"} synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases",

abstract = "By using {"}Click Chemistry{"}, we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.",

author = "Jun Wang and Mahesh Uttamchandani and Junqi Li and Mingyu Hu and Yao, {Shao Q.}",

year = "2006",

doi = "10.1039/b609446e",

language = "English (US)",

pages = "3783--3785",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - "Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

AU - Wang, Jun

AU - Uttamchandani, Mahesh

AU - Li, Junqi

AU - Hu, Mingyu

AU - Yao, Shao Q.

PY - 2006

Y1 - 2006

N2 - By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.

AB - By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.

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UR - http://www.scopus.com/inward/citedby.url?scp=33748701072&partnerID=8YFLogxK

U2 - 10.1039/b609446e

DO - 10.1039/b609446e

M3 - Article

C2 - 16969456

AN - SCOPUS:33748701072

SN - 1359-7345

SP - 3783

EP - 3785

JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

"Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Abstract

ASJC Scopus subject areas

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