Classical eyeblink conditioning in two strains of mice: Conditioned responses, sensitization, and spontaneous eyeblinks

Shaowen Bao, Lu Chen, Richard F. Thompson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Conditioned eyeblink responses (CRs), sensitization, and spontaneous eyeblinks were studied in C57BL/6J and BALB/c mice. Both strains of mice acquired CRs during 10 days of classical delay eyeblink conditioning. The BALB/c mice reached a higher asymptotic CR level than the C57BL/6J mice. The CRs were extinguished and recovered in both strains following conditioned stimulus-alone and paired conditioned stimulus-unconditioned stimulus training. During 10 days of explicitly unpaired training, the control groups showed no signs of sensitization and low incidence of spontaneous eyeblinks. When switched to paired training, the unpaired groups exhibited significant conditioned inhibition. These results suggest that strain differences must be considered in experimental design and data interpretation for these basic aspects of associative learning and memory.

Original languageEnglish (US)
Pages (from-to)714-718
Number of pages5
JournalBehavioral Neuroscience
Volume112
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience

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