Class i lysine deacetylases facilitate glucocorticoid-induced transcription

Vineela Kadiyala; Nina M. Patrick; Wana Mathieu; Rosa Jaime-Frias; Naruekamol Pookhao; Lingling An; Catharine L. Smith

doi:10.1074/jbc.M113.505115

Class i lysine deacetylases facilitate glucocorticoid-induced transcription

Vineela Kadiyala, Nina M. Patrick, Wana Mathieu, Rosa Jaime-Frias, Naruekamol Pookhao, Lingling An, Catharine L. Smith

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20 Scopus citations

Abstract

Background:KDACis impair GR transactivation of the MMTV promoter, but their impact on cellular target genes is unknown. Results:KDACi or KDAC depletion suppresses transactivation of about 50% of GR target genes. Conclusion:KDAC1 is required for efficient GR transactivation in a gene-selective fashion. Significance:Because KDACs facilitate GR transactivation, clinical KDACi use may have a major impact on GR signaling.

Original language	English (US)
Pages (from-to)	28900-28912
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.505115
State	Published - Oct 4 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Class i lysine deacetylases facilitate glucocorticoid-induced transcription",

abstract = "Background:KDACis impair GR transactivation of the MMTV promoter, but their impact on cellular target genes is unknown. Results:KDACi or KDAC depletion suppresses transactivation of about 50% of GR target genes. Conclusion:KDAC1 is required for efficient GR transactivation in a gene-selective fashion. Significance:Because KDACs facilitate GR transactivation, clinical KDACi use may have a major impact on GR signaling.",

author = "Vineela Kadiyala and Patrick, {Nina M.} and Wana Mathieu and Rosa Jaime-Frias and Naruekamol Pookhao and Lingling An and Smith, {Catharine L.}",

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AU - Kadiyala, Vineela

AU - Patrick, Nina M.

AU - Mathieu, Wana

AU - Jaime-Frias, Rosa

AU - Pookhao, Naruekamol

AU - An, Lingling

AU - Smith, Catharine L.

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:KDACis impair GR transactivation of the MMTV promoter, but their impact on cellular target genes is unknown. Results:KDACi or KDAC depletion suppresses transactivation of about 50% of GR target genes. Conclusion:KDAC1 is required for efficient GR transactivation in a gene-selective fashion. Significance:Because KDACs facilitate GR transactivation, clinical KDACi use may have a major impact on GR signaling.

AB - Background:KDACis impair GR transactivation of the MMTV promoter, but their impact on cellular target genes is unknown. Results:KDACi or KDAC depletion suppresses transactivation of about 50% of GR target genes. Conclusion:KDAC1 is required for efficient GR transactivation in a gene-selective fashion. Significance:Because KDACs facilitate GR transactivation, clinical KDACi use may have a major impact on GR signaling.

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JO - Journal of Biological Chemistry

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Class i lysine deacetylases facilitate glucocorticoid-induced transcription

Abstract

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