TY - JOUR
T1 - Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods
AU - Killgore, William D.S.
AU - Ross, Amy J.
AU - Kamiya, Toshikazu
AU - Kawada, Yoko
AU - Renshaw, Perry F.
AU - Yurgelun-Todd, Deborah A.
PY - 2010/1
Y1 - 2010/1
N2 - Objective: Cytidine-5′-diphosphocholine (citicoline) has a variety of cognitive enhancing, neuroprotective, and neuroregenerative properties. In cocaine-addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain responses to food are unknown. Method: We compared the effects of treatment with Cognizin® citicoline (500 mg/day versus 2,000 mg/day) for 6 weeks on changes in appetite ratings, weight, and cortico-limbic responses to images of high-calorie foods using functional magnetic resonance imaging (fMRI). Results: After 6 weeks, there was no significant change in weight status, although significant declines in appetite ratings were observed for the 2,000 mg/day group. The higher dose group also showed significant increases in functional brain responses to food stimuli within the amygdala, insula, and lateral orbitofrontal cortex. Increased activation in these regions correlated with declines in appetite ratings. Discussion: These preliminary findings suggest a potential usefulness of citicoline in modulating appetite, but further research is warranted.
AB - Objective: Cytidine-5′-diphosphocholine (citicoline) has a variety of cognitive enhancing, neuroprotective, and neuroregenerative properties. In cocaine-addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain responses to food are unknown. Method: We compared the effects of treatment with Cognizin® citicoline (500 mg/day versus 2,000 mg/day) for 6 weeks on changes in appetite ratings, weight, and cortico-limbic responses to images of high-calorie foods using functional magnetic resonance imaging (fMRI). Results: After 6 weeks, there was no significant change in weight status, although significant declines in appetite ratings were observed for the 2,000 mg/day group. The higher dose group also showed significant increases in functional brain responses to food stimuli within the amygdala, insula, and lateral orbitofrontal cortex. Increased activation in these regions correlated with declines in appetite ratings. Discussion: These preliminary findings suggest a potential usefulness of citicoline in modulating appetite, but further research is warranted.
KW - Amygdala
KW - Appetite
KW - Citocoline
KW - Cytidine-5′-diphosphocholine
KW - FMRI
KW - Food
KW - Insula
KW - Neuroimaging
KW - Orbitofrontal cortex
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U2 - 10.1002/eat.20658
DO - 10.1002/eat.20658
M3 - Article
C2 - 19260039
AN - SCOPUS:74049097441
SN - 0276-3478
VL - 43
SP - 6
EP - 13
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
IS - 1
ER -