Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

Øivind Midttun, Despoina Theofylaktopoulou, Adrian McCann, Anouar Fanidi, David C. Muller, Klaus Meyer, Arve Ulvik, Wei Zheng, Xiao Ou Shu, Yong Bing Xiang, Ross Prentice, Cynthia A. Thomson, Mary Pettinger, Graham G. Giles, Allison Hodge, Qiuyin Cai, William J. Blot, Jie Wu, Mikael Johansson, Johan HultdinKjell Grankvist, Victoria L. Stevens, Marjorie L. McCullough, Stephanie J. Weinstein, Demetrius Albanes, Arnulf Langhammer, Kristian Hveem, Marit Næss, Howard D. Sesso, J. Michael Gaziano, Julie E. Buring, I. Min Lee, Gianluca Severi, Xuehong Zhang, Jiali Han, Meir J. Stampfer, Stephanie A. Smith-Warner, Anne Zeleniuch-Jacquotte, Loic Le Marchand, Jian Min Yuan, Lesley M. Butler, Woon Puay Koh, Renwei Wang, Yu Tang Gao, Ulrika Ericson, Emily Sonestedt, Regina G. Ziegler, Neal D. Freedman, Kala Visvanathan, Miranda R. Jones, Caroline Relton, Paul Brennan, Mattias Johansson, Per M. Ueland

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

Original languageEnglish (US)
Pages (from-to)1314-1326
Number of pages13
JournalAmerican Journal of Clinical Nutrition
Issue number6
StatePublished - Jun 1 2017


  • Biomarker
  • Lung Cancer Cohort Consortium
  • One-carbon metabolism
  • Tryptophan metabolism
  • Vitamin status

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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