Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying

E. Spanos; J. W. Pike; M. R. Haussler; K. W. Colston; I. M.A. Evans; A. M. Goldner; T. A. McCain; I. MacIntyre

doi:10.1016/0024-3205(76)90083-7

Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying

E. Spanos, J. W. Pike, M. R. Haussler, K. W. Colston, I. M.A. Evans, A. M. Goldner, T. A. McCain, I. MacIntyre

Basic Medical Sciences, Phoenix

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1α,25-dihydroxyvitamin D (1α,25-(OH)₂D) was measured by radioreceptor assay in chicks given injections of prolactin for five days. At a dose of 100 μg/day, the lactogenic hormone elicited a two-fold increase in plasma 1α,25-(OH)₂D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which calcuim absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1α,25-(OH)₂D in the laying hen demonstrates a nine-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1α,25-(OH)₂D is suggested.

Original language	English (US)
Pages (from-to)	1751-1756
Number of pages	6
Journal	Life Sciences
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(76)90083-7
State	Published - Dec 1 1976

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(76)90083-7

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title = "Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying",

abstract = "In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1α,25-dihydroxyvitamin D (1α,25-(OH)2D) was measured by radioreceptor assay in chicks given injections of prolactin for five days. At a dose of 100 μg/day, the lactogenic hormone elicited a two-fold increase in plasma 1α,25-(OH)2D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which calcuim absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1α,25-(OH)2D in the laying hen demonstrates a nine-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1α,25-(OH)2D is suggested.",

author = "E. Spanos and Pike, {J. W.} and Haussler, {M. R.} and Colston, {K. W.} and Evans, {I. M.A.} and Goldner, {A. M.} and McCain, {T. A.} and I. MacIntyre",

note = "Funding Information: This research wen supported in part by grants from the Wellcome Trust and Medical Research Council and NIH Grant AM 15781 . We thank Joeeph Zexwekh and Adrienne Sainten for help in processing the plasma for 1x,25-(OH)2D assay, and Jean Hrueka of the University of Arizona Department of Animal Sciences for assistance in obtaining blood samples from hens . Pleeae direct all correspondence to Professor Iein MacIntyre at the Royal Postgraduate Medical School .",

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doi = "10.1016/0024-3205(76)90083-7",

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T1 - Circulating 1α,25-dihydroxyvitamin D in the chicken

T2 - Enhancement by injection of prolactin and during egg laying

AU - Spanos, E.

AU - Pike, J. W.

AU - Haussler, M. R.

AU - Colston, K. W.

AU - Evans, I. M.A.

AU - Goldner, A. M.

AU - McCain, T. A.

AU - MacIntyre, I.

N1 - Funding Information: This research wen supported in part by grants from the Wellcome Trust and Medical Research Council and NIH Grant AM 15781 . We thank Joeeph Zexwekh and Adrienne Sainten for help in processing the plasma for 1x,25-(OH)2D assay, and Jean Hrueka of the University of Arizona Department of Animal Sciences for assistance in obtaining blood samples from hens . Pleeae direct all correspondence to Professor Iein MacIntyre at the Royal Postgraduate Medical School .

PY - 1976/12/1

Y1 - 1976/12/1

N2 - In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1α,25-dihydroxyvitamin D (1α,25-(OH)2D) was measured by radioreceptor assay in chicks given injections of prolactin for five days. At a dose of 100 μg/day, the lactogenic hormone elicited a two-fold increase in plasma 1α,25-(OH)2D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which calcuim absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1α,25-(OH)2D in the laying hen demonstrates a nine-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1α,25-(OH)2D is suggested.

AB - In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1α,25-dihydroxyvitamin D (1α,25-(OH)2D) was measured by radioreceptor assay in chicks given injections of prolactin for five days. At a dose of 100 μg/day, the lactogenic hormone elicited a two-fold increase in plasma 1α,25-(OH)2D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which calcuim absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1α,25-(OH)2D in the laying hen demonstrates a nine-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1α,25-(OH)2D is suggested.

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Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying

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