TY - JOUR
T1 - Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults
AU - Hausman, Hanna K.
AU - Hardcastle, Cheshire
AU - Albizu, Alejandro
AU - Kraft, Jessica N.
AU - Evangelista, Nicole D.
AU - Boutzoukas, Emanuel M.
AU - Langer, Kailey
AU - O’Shea, Andrew
AU - Van Etten, Emily J.
AU - Bharadwaj, Pradyumna K.
AU - Song, Hyun
AU - Smith, Samantha G.
AU - Porges, Eric
AU - DeKosky, Steven T.
AU - Hishaw, Georg A.
AU - Wu, Samuel
AU - Marsiske, Michael
AU - Cohen, Ronald
AU - Alexander, Gene E.
AU - Woods, Adam J.
N1 - Funding Information:
This work was supported by the National Institute on Aging [NIA R01AG054077, NIA K01AG050707, NIA P30AG072980, T32AG020499], the State of Arizona and Arizona Department of Health Services (ADHS), the University of Florida Center for Cognitive Aging and Memory Clinical Translational Research, the McKnight Brain Research Foundation, and National Heart, Lung, and Blood Institute [T32HL134621].
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to American Aging Association.
PY - 2022/4
Y1 - 2022/4
N2 - Executive function is a cognitive domain that typically declines in non-pathological aging. Two cognitive control networks that are vulnerable to aging—the cingulo-opercular (CON) and fronto-parietal control (FPCN) networks—play a role in various aspects of executive functioning. However, it is unclear how communication within these networks at rest relates to executive function subcomponents in older adults. This study examines the associations between CON and FPCN connectivity and executive function performance in 274 older adults across working memory, inhibition, and set-shifting tasks. Average CON connectivity was associated with better working memory, inhibition, and set-shifting performance, while average FPCN connectivity was associated solely with working memory. CON region of interest analyses revealed significant connections with classical hub regions (i.e., anterior cingulate and anterior insula) for each task, language regions for verbal working memory, right hemisphere dominance for inhibitory control, and widespread network connections for set-shifting. FPCN region of interest analyses revealed largely right hemisphere fronto-parietal connections important for working memory and a few temporal lobe connections for set-shifting. These findings characterize differential brain-behavior relationships between cognitive control networks and executive function in aging. Future research should target these networks for intervention to potentially attenuate executive function decline in older adults.
AB - Executive function is a cognitive domain that typically declines in non-pathological aging. Two cognitive control networks that are vulnerable to aging—the cingulo-opercular (CON) and fronto-parietal control (FPCN) networks—play a role in various aspects of executive functioning. However, it is unclear how communication within these networks at rest relates to executive function subcomponents in older adults. This study examines the associations between CON and FPCN connectivity and executive function performance in 274 older adults across working memory, inhibition, and set-shifting tasks. Average CON connectivity was associated with better working memory, inhibition, and set-shifting performance, while average FPCN connectivity was associated solely with working memory. CON region of interest analyses revealed significant connections with classical hub regions (i.e., anterior cingulate and anterior insula) for each task, language regions for verbal working memory, right hemisphere dominance for inhibitory control, and widespread network connections for set-shifting. FPCN region of interest analyses revealed largely right hemisphere fronto-parietal connections important for working memory and a few temporal lobe connections for set-shifting. These findings characterize differential brain-behavior relationships between cognitive control networks and executive function in aging. Future research should target these networks for intervention to potentially attenuate executive function decline in older adults.
KW - Cognitive aging
KW - Executive function
KW - Imaging
KW - Resting-state networks
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U2 - 10.1007/s11357-021-00503-1
DO - 10.1007/s11357-021-00503-1
M3 - Article
C2 - 34950997
AN - SCOPUS:85121599888
SN - 2509-2715
VL - 44
SP - 847
EP - 866
JO - GeroScience
JF - GeroScience
IS - 2
ER -