Cinchona alkaloid based thiourea promoted enantioselective conjugate addition of N-heterocycles to enones

Jian Wang, Liansuo Zu, Hao Li, Hexin Xie, Wei Wang

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The first enantioselective conjugate addition reaction of 1H-benzotriazole with a variety of enones has been developed. The process, catalyzed by a cinchona alkaloid thiourea, affords Michael adducts in good yields and with moderate to good enantioselectivities.

Original languageEnglish (US)
Pages (from-to)2576-2580
Number of pages5
JournalSynthesis
Issue number16
DOIs
StatePublished - Aug 16 2007
Externally publishedYes

Keywords

  • Alkaloids
  • Conjugate additions
  • Enones
  • N-heterocycles
  • Thioureas

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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