Cinchona alkaloid based thiourea promoted enantioselective conjugate addition of N-heterocycles to enones

Jian Wang; Liansuo Zu; Hao Li; Hexin Xie; Wei Wang

doi:10.1055/s-2007-983786

Cinchona alkaloid based thiourea promoted enantioselective conjugate addition of N-heterocycles to enones

Jian Wang, Liansuo Zu, Hao Li, Hexin Xie, Wei Wang

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The first enantioselective conjugate addition reaction of 1H-benzotriazole with a variety of enones has been developed. The process, catalyzed by a cinchona alkaloid thiourea, affords Michael adducts in good yields and with moderate to good enantioselectivities.

Original language	English (US)
Pages (from-to)	2576-2580
Number of pages	5
Journal	Synthesis
Issue number	16
DOIs	https://doi.org/10.1055/s-2007-983786
State	Published - Aug 16 2007
Externally published	Yes

Keywords

Alkaloids
Conjugate additions
Enones
N-heterocycles
Thioureas

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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title = "Cinchona alkaloid based thiourea promoted enantioselective conjugate addition of N-heterocycles to enones",

abstract = "The first enantioselective conjugate addition reaction of 1H-benzotriazole with a variety of enones has been developed. The process, catalyzed by a cinchona alkaloid thiourea, affords Michael adducts in good yields and with moderate to good enantioselectivities.",

keywords = "Alkaloids, Conjugate additions, Enones, N-heterocycles, Thioureas",

author = "Jian Wang and Liansuo Zu and Hao Li and Hexin Xie and Wei Wang",

year = "2007",

month = aug,

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doi = "10.1055/s-2007-983786",

language = "English (US)",

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T1 - Cinchona alkaloid based thiourea promoted enantioselective conjugate addition of N-heterocycles to enones

AU - Wang, Jian

AU - Zu, Liansuo

AU - Li, Hao

AU - Xie, Hexin

AU - Wang, Wei

PY - 2007/8/16

Y1 - 2007/8/16

N2 - The first enantioselective conjugate addition reaction of 1H-benzotriazole with a variety of enones has been developed. The process, catalyzed by a cinchona alkaloid thiourea, affords Michael adducts in good yields and with moderate to good enantioselectivities.

AB - The first enantioselective conjugate addition reaction of 1H-benzotriazole with a variety of enones has been developed. The process, catalyzed by a cinchona alkaloid thiourea, affords Michael adducts in good yields and with moderate to good enantioselectivities.

KW - Alkaloids

KW - Conjugate additions

KW - Enones

KW - N-heterocycles

KW - Thioureas

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U2 - 10.1055/s-2007-983786

DO - 10.1055/s-2007-983786

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Cinchona alkaloid based thiourea promoted enantioselective conjugate addition of N-heterocycles to enones

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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