Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

FREDERICK J. KOGAN; RICHARD E. SAMPLINER; MICHAEL MAYERSOHN; RODNEY M. KAZAMA; DONALD PERRIER; WILLIAM JONES; ULRICH F. MICHAEL

doi:10.1002/j.1552-4604.1983.tb02732.x

Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

FREDERICK J. KOGAN, RICHARD E. SAMPLINER, MICHAEL MAYERSOHN, RODNEY M. KAZAMA, DONALD PERRIER, WILLIAM JONES, ULRICH F. MICHAEL

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Abstract: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis. 1983 American College of Clinical Pharmacology

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	The Journal of Clinical Pharmacology
Volume	23
Issue number	5-6
DOIs	https://doi.org/10.1002/j.1552-4604.1983.tb02732.x
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis",

abstract = "Abstract: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis. 1983 American College of Clinical Pharmacology",

author = "KOGAN, {FREDERICK J.} and SAMPLINER, {RICHARD E.} and MICHAEL MAYERSOHN and KAZAMA, {RODNEY M.} and DONALD PERRIER and WILLIAM JONES and MICHAEL, {ULRICH F.}",

year = "1983",

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T1 - Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

AU - KOGAN, FREDERICK J.

AU - SAMPLINER, RICHARD E.

AU - MAYERSOHN, MICHAEL

AU - KAZAMA, RODNEY M.

AU - PERRIER, DONALD

AU - JONES, WILLIAM

AU - MICHAEL, ULRICH F.

PY - 1983

Y1 - 1983

N2 - Abstract: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis. 1983 American College of Clinical Pharmacology

AB - Abstract: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis. 1983 American College of Clinical Pharmacology

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Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

Abstract

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