TY - JOUR
T1 - Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance
AU - Yuan, Robin K.
AU - Zitting, Kirsi Marja
AU - Duffy, Jeanne F.
AU - Vujovic, Nina
AU - Wang, Wei
AU - Quan, Stuart F.
AU - Klerman, Elizabeth B.
AU - Scheer, Frank A.J.L.
AU - Buxton, Orfeu M.
AU - Williams, Jonathan S.
AU - Czeisler, Charles A.
N1 - Funding Information:
We thank the research volunteers for their participation in the studies, Brigham and Women?s Hospital Center for Clinical Investigation (CCI) dietary, nursing and technical staff and the Division of Sleep and Circadian Disorders Sleep Core (Brandon Lockyer, Daniel Aeschbach), and Chronobiology Core (Jacob Medina, Alec Rader, Gina Daniels, Arick Wong, John Slingerland, Michael Harris, Julia Boudreau, Kyoko Hashimoto, John Wise, Divya Mohan, Audra Murphy, and Northeastern University co-ops) for their assistance with data collection. We thank the study recruiters, Gina Daniels, Alec Rader, and Jacob Medina. We also thank the following individuals for their contributions: Gail Adler, Jae Wook Cho, Cheryl Isherwood, Bruce Kristal, Ciaran McMullan, Connor O?Brian, and Joe Ronda.
Funding Information:
This study was supported by a grant from the National Institute on Aging (P01 AG009975) and a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK127254) and was conducted at the Brigham and Women’s Hospital Center for Clinical Investigation, part of Harvard Catalyst (Harvard Clinical and Translational Science Center) supported
Publisher Copyright:
Copyright © 2021 Yuan, Zitting, Duffy, Vujovic, Wang, Quan, Klerman, Scheer, Buxton, Williams and Czeisler.
PY - 2021/10/20
Y1 - 2021/10/20
N2 - Insufficient sleep, which has been shown to adversely affect metabolism, is generally associated with prolonged exposure to artificial light at night, a known circadian disruptor. There is growing evidence suggesting that circadian disruption adversely affects metabolism, yet few studies have attempted to evaluate the adverse metabolic effects of insufficient sleep while controlling for circadian disruption. We assessed postprandial glucose and insulin responses to a standard breakfast meal in healthy adults (n = 9) who underwent 3 weeks of chronic sleep restriction (CSR) in a 37-day inpatient study while minimizing circadian disruption by maintaining the same duration of light exposure each study day. We compared these results to findings from an earlier inpatient study which used a forced desynchrony (FD) protocol to assess the influence of 3 weeks of CSR combined with recurrent circadian disruption (RCD) on glycemic control in healthy adults (n = 21). CSR combined with RCD resulted in significantly elevated postprandial plasma glucose levels (p < 0.0001), while CSR with minimized circadian disruption had no adverse glycemic effects after 3 weeks of exposure (EXP). These results suggest that one mechanism by which sleep restriction impacts metabolism may be via concurrent circadian disruption.
AB - Insufficient sleep, which has been shown to adversely affect metabolism, is generally associated with prolonged exposure to artificial light at night, a known circadian disruptor. There is growing evidence suggesting that circadian disruption adversely affects metabolism, yet few studies have attempted to evaluate the adverse metabolic effects of insufficient sleep while controlling for circadian disruption. We assessed postprandial glucose and insulin responses to a standard breakfast meal in healthy adults (n = 9) who underwent 3 weeks of chronic sleep restriction (CSR) in a 37-day inpatient study while minimizing circadian disruption by maintaining the same duration of light exposure each study day. We compared these results to findings from an earlier inpatient study which used a forced desynchrony (FD) protocol to assess the influence of 3 weeks of CSR combined with recurrent circadian disruption (RCD) on glycemic control in healthy adults (n = 21). CSR combined with RCD resulted in significantly elevated postprandial plasma glucose levels (p < 0.0001), while CSR with minimized circadian disruption had no adverse glycemic effects after 3 weeks of exposure (EXP). These results suggest that one mechanism by which sleep restriction impacts metabolism may be via concurrent circadian disruption.
KW - chronic sleep restriction
KW - glucose tolerance
KW - insulin sensitivity
KW - metabolism
KW - recurrent circadian disruption
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U2 - 10.3389/fphys.2021.764737
DO - 10.3389/fphys.2021.764737
M3 - Article
AN - SCOPUS:85118641475
SN - 1664-042X
VL - 12
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 764737
ER -