Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance

Robin K. Yuan, Kirsi Marja Zitting, Jeanne F. Duffy, Nina Vujovic, Wei Wang, Stuart F. Quan, Elizabeth B. Klerman, Frank A.J.L. Scheer, Orfeu M. Buxton, Jonathan S. Williams, Charles A. Czeisler

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations


    Insufficient sleep, which has been shown to adversely affect metabolism, is generally associated with prolonged exposure to artificial light at night, a known circadian disruptor. There is growing evidence suggesting that circadian disruption adversely affects metabolism, yet few studies have attempted to evaluate the adverse metabolic effects of insufficient sleep while controlling for circadian disruption. We assessed postprandial glucose and insulin responses to a standard breakfast meal in healthy adults (n = 9) who underwent 3 weeks of chronic sleep restriction (CSR) in a 37-day inpatient study while minimizing circadian disruption by maintaining the same duration of light exposure each study day. We compared these results to findings from an earlier inpatient study which used a forced desynchrony (FD) protocol to assess the influence of 3 weeks of CSR combined with recurrent circadian disruption (RCD) on glycemic control in healthy adults (n = 21). CSR combined with RCD resulted in significantly elevated postprandial plasma glucose levels (p < 0.0001), while CSR with minimized circadian disruption had no adverse glycemic effects after 3 weeks of exposure (EXP). These results suggest that one mechanism by which sleep restriction impacts metabolism may be via concurrent circadian disruption.

    Original languageEnglish (US)
    Article number764737
    JournalFrontiers in Physiology
    StatePublished - Oct 20 2021


    • chronic sleep restriction
    • glucose tolerance
    • insulin sensitivity
    • metabolism
    • recurrent circadian disruption

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)


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