Chlorpromazine effects upon rabbit lens water and electrolyte balance

Cathryn C. Wilson; Nicholas A. Delamere; Christopher A. Paterson

doi:10.1016/0014-4835(83)90050-7

Chlorpromazine effects upon rabbit lens water and electrolyte balance

Cathryn C. Wilson, Nicholas A. Delamere, Christopher A. Paterson

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Chlorpromazine (CPZ) concentrations of 5 × 10^-5 m or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. ⁸⁶Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.

Original language	English (US)
Pages (from-to)	559-565
Number of pages	7
Journal	Experimental eye research
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/0014-4835(83)90050-7
State	Published - Apr 1983

Keywords

calcium
cataract
chlorpromazine
lens hydration
permeability
potassium
rabbit lens
sodium
sodium pump

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(83)90050-7

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title = "Chlorpromazine effects upon rabbit lens water and electrolyte balance",

abstract = "Chlorpromazine (CPZ) concentrations of 5 × 10-5 m or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.",

keywords = "calcium, cataract, chlorpromazine, lens hydration, permeability, potassium, rabbit lens, sodium, sodium pump",

author = "Wilson, {Cathryn C.} and Delamere, {Nicholas A.} and Paterson, {Christopher A.}",

year = "1983",

month = apr,

doi = "10.1016/0014-4835(83)90050-7",

language = "English (US)",

volume = "36",

pages = "559--565",

journal = "Experimental Eye Research",

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TY - JOUR

T1 - Chlorpromazine effects upon rabbit lens water and electrolyte balance

AU - Wilson, Cathryn C.

AU - Delamere, Nicholas A.

AU - Paterson, Christopher A.

PY - 1983/4

Y1 - 1983/4

N2 - Chlorpromazine (CPZ) concentrations of 5 × 10-5 m or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.

AB - Chlorpromazine (CPZ) concentrations of 5 × 10-5 m or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.

KW - calcium

KW - cataract

KW - chlorpromazine

KW - lens hydration

KW - permeability

KW - potassium

KW - rabbit lens

KW - sodium

KW - sodium pump

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JO - Experimental Eye Research

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Chlorpromazine effects upon rabbit lens water and electrolyte balance

Abstract

Keywords

ASJC Scopus subject areas

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