Chloro polyketides from the cultured fungus (Aspergillus) separated from a marine sponge

Leif M. Abrell; Bethel Borgeson; Phillip Crews

doi:10.1016/0040-4039(96)00277-8

Chloro polyketides from the cultured fungus (Aspergillus) separated from a marine sponge

Leif M. Abrell, Bethel Borgeson, Phillip Crews

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The salt water culture of Aspergillus ?ochraceus separated from the Indo-Pacific sponge Jaspis cf. coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (1a) and B (1b). These compounds have an overall structural analogy to carolic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides are reported. Also noted are the similarities of their α-methylene-γ-butyrolactones to those of the litsenolides and mahubenolides, both derived from plants.

Original language	English (US)
Pages (from-to)	2331-2334
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	14
DOIs	https://doi.org/10.1016/0040-4039(96)00277-8
State	Published - Apr 1 1996
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(96)00277-8

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abstract = "The salt water culture of Aspergillus ?ochraceus separated from the Indo-Pacific sponge Jaspis cf. coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (1a) and B (1b). These compounds have an overall structural analogy to carolic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides are reported. Also noted are the similarities of their α-methylene-γ-butyrolactones to those of the litsenolides and mahubenolides, both derived from plants.",

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AU - Abrell, Leif M.

AU - Borgeson, Bethel

AU - Crews, Phillip

PY - 1996/4/1

Y1 - 1996/4/1

N2 - The salt water culture of Aspergillus ?ochraceus separated from the Indo-Pacific sponge Jaspis cf. coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (1a) and B (1b). These compounds have an overall structural analogy to carolic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides are reported. Also noted are the similarities of their α-methylene-γ-butyrolactones to those of the litsenolides and mahubenolides, both derived from plants.

AB - The salt water culture of Aspergillus ?ochraceus separated from the Indo-Pacific sponge Jaspis cf. coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (1a) and B (1b). These compounds have an overall structural analogy to carolic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides are reported. Also noted are the similarities of their α-methylene-γ-butyrolactones to those of the litsenolides and mahubenolides, both derived from plants.

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Chloro polyketides from the cultured fungus (Aspergillus) separated from a marine sponge

Abstract

ASJC Scopus subject areas

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