TY - JOUR
T1 - Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release
AU - Yuan, Zeting
AU - Ye, Yajing
AU - Gao, Feng
AU - Yuan, Huihui
AU - Lan, Minbo
AU - Lou, Kaiyan
AU - Wang, Wei
N1 - Funding Information:
The authors acknowledge the financial support from the Fundamental Research Funds for the Central Universities ( WY1213013 ECUST ), Shanghai Nanotechnology Leading Academic Discipline Foundation (No. 0852nm05900 ) and 111 Program of China (No. B07023 ). This work was also supported by Shanghai Committee of Science and Technology (Grant No. 10DZ2220500 and 11DZ2260600 ).
PY - 2013/3/25
Y1 - 2013/3/25
N2 - Chitosan (CS) grafted with β-cyclodextrin (CD-g-CS) nanoparticles as a new carrier for poorly water-soluble drugs has been developed. The CD-g-CS polymer is readily synthesized from chitosan and mono-6-deoxy-6-(p- toluenesulfonyl)-β-cyclodextrin. Three different degrees of substitution (DS) of β-cyclodextrin (β-CD) on CD-g-CS (9.6, 14.0 and 20.0%) are designed and evaluated by controlling the mole ratio of β-CD to chitosan. Then CD-g-CS nanoparticles are prepared by an ionic gelation method, with the controlled size of 202.0-589.0 nm. Stable colloidal dispersion of the nanoparticles has been formed with the zeta potential of +23.0 to +43.0 mV. In vitro stability test indicates that CD-g-CS nanoparticles are more stable in phosphate-buffered saline compared with CS nanoparticles. Finally, the poorly water-soluble drug, ketoprofen (KTP), is used as a model drug to evaluate the efficiency of the new drug delivery carrier. It is found that the encapsulation efficiency of KTP in the nanoparticles with 20% DS of CD is as high as 1.36-fold than that of CS nanoparticles. Moreover, notably KTP is released from the nanoparticles in a controlled-release manner and is pH-responsive on DS of CD. In summary, these results suggest that the CD-g-CS nanoparticles, as a general promising drug delivery system, can be used as a potential biodegradable nano-drug delivery system for controlled release of poorly water-soluble drugs with pH-responsive capability.
AB - Chitosan (CS) grafted with β-cyclodextrin (CD-g-CS) nanoparticles as a new carrier for poorly water-soluble drugs has been developed. The CD-g-CS polymer is readily synthesized from chitosan and mono-6-deoxy-6-(p- toluenesulfonyl)-β-cyclodextrin. Three different degrees of substitution (DS) of β-cyclodextrin (β-CD) on CD-g-CS (9.6, 14.0 and 20.0%) are designed and evaluated by controlling the mole ratio of β-CD to chitosan. Then CD-g-CS nanoparticles are prepared by an ionic gelation method, with the controlled size of 202.0-589.0 nm. Stable colloidal dispersion of the nanoparticles has been formed with the zeta potential of +23.0 to +43.0 mV. In vitro stability test indicates that CD-g-CS nanoparticles are more stable in phosphate-buffered saline compared with CS nanoparticles. Finally, the poorly water-soluble drug, ketoprofen (KTP), is used as a model drug to evaluate the efficiency of the new drug delivery carrier. It is found that the encapsulation efficiency of KTP in the nanoparticles with 20% DS of CD is as high as 1.36-fold than that of CS nanoparticles. Moreover, notably KTP is released from the nanoparticles in a controlled-release manner and is pH-responsive on DS of CD. In summary, these results suggest that the CD-g-CS nanoparticles, as a general promising drug delivery system, can be used as a potential biodegradable nano-drug delivery system for controlled release of poorly water-soluble drugs with pH-responsive capability.
KW - Chitosan
KW - Cyclodextrin
KW - Ionic gelation
KW - Nano-drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=84874943447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874943447&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2013.02.024
DO - 10.1016/j.ijpharm.2013.02.024
M3 - Article
C2 - 23422276
AN - SCOPUS:84874943447
SN - 0378-5173
VL - 446
SP - 191
EP - 198
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -