Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides

Jian Wang, Man Man Zhang, Shieli Zhang, Zi An Xu, Hao Li, Xin Hong Yu, Wei Wang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

An organocatalytic enantioselective conjugate addition of cyclohexanones to maleimides has been developed. The process catalyzed by a (S)-pyrrolidine sulfonamide affords synthetically and medicinally useful chiral succinimides under mild reaction conditions.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalSynlett
Issue number4
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Michael reaction
  • cyclic ketones
  • maleimides
  • pyrrolidine sulfonamide

ASJC Scopus subject areas

  • Organic Chemistry

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