Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides

Jian Wang; Man Man Zhang; Shieli Zhang; Zi An Xu; Hao Li; Xin Hong Yu; Wei Wang

doi:10.1055/s-0030-1259517

Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides

Jian Wang, Man Man Zhang, Shieli Zhang, Zi An Xu, Hao Li, Xin Hong Yu, Wei Wang

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

An organocatalytic enantioselective conjugate addition of cyclohexanones to maleimides has been developed. The process catalyzed by a (S)-pyrrolidine sulfonamide affords synthetically and medicinally useful chiral succinimides under mild reaction conditions.

Original language	English (US)
Pages (from-to)	473-476
Number of pages	4
Journal	Synlett
Issue number	4
DOIs	https://doi.org/10.1055/s-0030-1259517
State	Published - 2011
Externally published	Yes

Keywords

Michael reaction
cyclic ketones
maleimides
pyrrolidine sulfonamide

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0030-1259517

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title = "Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides",

abstract = "An organocatalytic enantioselective conjugate addition of cyclohexanones to maleimides has been developed. The process catalyzed by a (S)-pyrrolidine sulfonamide affords synthetically and medicinally useful chiral succinimides under mild reaction conditions.",

keywords = "Michael reaction, cyclic ketones, maleimides, pyrrolidine sulfonamide",

author = "Jian Wang and Zhang, {Man Man} and Shieli Zhang and Xu, {Zi An} and Hao Li and Yu, {Xin Hong} and Wei Wang",

year = "2011",

doi = "10.1055/s-0030-1259517",

language = "English (US)",

pages = "473--476",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "4",

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TY - JOUR

T1 - Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides

AU - Wang, Jian

AU - Zhang, Man Man

AU - Zhang, Shieli

AU - Xu, Zi An

AU - Li, Hao

AU - Yu, Xin Hong

AU - Wang, Wei

PY - 2011

Y1 - 2011

N2 - An organocatalytic enantioselective conjugate addition of cyclohexanones to maleimides has been developed. The process catalyzed by a (S)-pyrrolidine sulfonamide affords synthetically and medicinally useful chiral succinimides under mild reaction conditions.

AB - An organocatalytic enantioselective conjugate addition of cyclohexanones to maleimides has been developed. The process catalyzed by a (S)-pyrrolidine sulfonamide affords synthetically and medicinally useful chiral succinimides under mild reaction conditions.

KW - Michael reaction

KW - cyclic ketones

KW - maleimides

KW - pyrrolidine sulfonamide

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UR - http://www.scopus.com/inward/citedby.url?scp=79951856418&partnerID=8YFLogxK

U2 - 10.1055/s-0030-1259517

DO - 10.1055/s-0030-1259517

M3 - Article

AN - SCOPUS:79951856418

SN - 0936-5214

SP - 473

EP - 476

JO - Synlett

JF - Synlett

IS - 4

ER -

Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides

Abstract

Keywords

ASJC Scopus subject areas

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