Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction

Jian Wang; Hao Li; Xinhong Yu; Liansuo Zu; Wei Wang

doi:10.1021/ol051822+

Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction

Jian Wang, Hao Li, Xinhong Yu, Liansuo Zu, Wei Wang

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Abstract

(Chemical Equation Presented) A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.

Original language	English (US)
Pages (from-to)	4293-4296
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	19
DOIs	https://doi.org/10.1021/ol051822+
State	Published - Sep 15 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol051822+

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abstract = "(Chemical Equation Presented) A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.",

author = "Jian Wang and Hao Li and Xinhong Yu and Liansuo Zu and Wei Wang",

year = "2005",

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T1 - Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction

AU - Wang, Jian

AU - Li, Hao

AU - Yu, Xinhong

AU - Zu, Liansuo

AU - Wang, Wei

PY - 2005/9/15

Y1 - 2005/9/15

N2 - (Chemical Equation Presented) A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.

AB - (Chemical Equation Presented) A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.

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JO - Organic Letters

JF - Organic Letters

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Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction

Abstract

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