Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction

Jian Wang, Hao Li, Xinhong Yu, Liansuo Zu, Wei Wang

Research output: Contribution to journalArticlepeer-review

263 Scopus citations

Abstract

(Chemical Equation Presented) A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.

Original languageEnglish (US)
Pages (from-to)4293-4296
Number of pages4
JournalOrganic Letters
Volume7
Issue number19
DOIs
StatePublished - Sep 15 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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