Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1976|
ASJC Scopus subject areas
- Cancer Research