Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study

S. P. Richman; R. B. Livingston; J. U. Gutterman; J. Y. Suen; E. M. Hersh

Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study

S. P. Richman, R. B. Livingston, J. U. Gutterman, J. Y. Suen, E. M. Hersh

Research output: Contribution to journal › Article › peer-review

Abstract

Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.

Original language	English (US)
Pages (from-to)	535-539
Number of pages	5
Journal	Unknown Journal
Volume	60
Issue number	5
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study",

abstract = "Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.",

author = "Richman, {S. P.} and Livingston, {R. B.} and Gutterman, {J. U.} and Suen, {J. Y.} and Hersh, {E. M.}",

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T1 - Chemotherapy versus chemoimmunotherapy of head and neck cancer

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AU - Richman, S. P.

AU - Livingston, R. B.

AU - Gutterman, J. U.

AU - Suen, J. Y.

AU - Hersh, E. M.

PY - 1976

Y1 - 1976

N2 - Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.

AB - Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.

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Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study

Abstract

ASJC Scopus subject areas

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