TY - JOUR
T1 - Chemotherapy of advanced dysgerminoma
T2 - Trials of the gynecologic oncology group
AU - Williams, Stephen D.
AU - Blessing, John A.
AU - Hatch, Kenneth D.
AU - Homesley, Howard D.
PY - 1991/11
Y1 - 1991/11
N2 - Between 1984 and 1989, 20 assessable patients with incompletely resected ovarian dysgerminoma were treated on two protocols of the Gynecologic Oncology Group (GOG). All patients received cisplatin, bleomycin, and either vinblastine or etoposide. More recent patients also received consolidation chemotherapy with vincristine, dactinomycin, and cyclophosphamide (VAC). Eleven patients had clinically measurable disease, and 10 responded completely. Fourteen second-look procedures were done, and all were negative. Currently, 19 of 20 patients are disease-free with median follow-up of 26 months. Cisplatin-based chemotherapy is highly effective in patients with advanced dysgerminoma.
AB - Between 1984 and 1989, 20 assessable patients with incompletely resected ovarian dysgerminoma were treated on two protocols of the Gynecologic Oncology Group (GOG). All patients received cisplatin, bleomycin, and either vinblastine or etoposide. More recent patients also received consolidation chemotherapy with vincristine, dactinomycin, and cyclophosphamide (VAC). Eleven patients had clinically measurable disease, and 10 responded completely. Fourteen second-look procedures were done, and all were negative. Currently, 19 of 20 patients are disease-free with median follow-up of 26 months. Cisplatin-based chemotherapy is highly effective in patients with advanced dysgerminoma.
UR - http://www.scopus.com/inward/record.url?scp=0026005129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026005129&partnerID=8YFLogxK
U2 - 10.1200/JCO.1991.9.11.1950
DO - 10.1200/JCO.1991.9.11.1950
M3 - Article
C2 - 1719142
AN - SCOPUS:0026005129
SN - 0732-183X
VL - 9
SP - 1950
EP - 1955
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 11
ER -