Chemoprevention of human skin cancers

Lois J. Loescher; Frank L. Meyskens

doi:10.1016/0749-2081(91)90054-S

Chemoprevention of human skin cancers

Lois J. Loescher, Frank L. Meyskens

Nursing, College of

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Original language	English (US)
Pages (from-to)	45-52
Number of pages	8
Journal	Seminars in oncology nursing
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0749-2081(91)90054-S
State	Published - Feb 1991

ASJC Scopus subject areas

Oncology(nursing)

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10.1016/0749-2081(91)90054-S

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@article{7f52d670c3f54d29a99938406d21916a,

title = "Chemoprevention of human skin cancers",

author = "Loescher, {Lois J.} and Meyskens, {Frank L.}",

note = "Funding Information: In humans, oral DFMO has resulted in severe dose-related toxicities (gastrointestinal, neurologic, and hematologic toxicities, fatigue, rash, arthralgias, alopecia, high frequency hearing loss), necessitating discontinuation of the drug.5{\textquoteright} It has also been known to cause teratogenesis and induce abortions in animals. Little is known about the toxicity of topical DFMO, but when administered to UVB-irradiated mice, the toxicity of topical DFMO was minimal (personal communication, H. Gensler, February 1990). A chemoprevention trial funded by the National Cancer Institute is underway at the University of Arizona Cancer Center using topical DFMO and vitamin E in human subjects with actinic keratoses.",

year = "1991",

month = feb,

doi = "10.1016/0749-2081(91)90054-S",

language = "English (US)",

volume = "7",

pages = "45--52",

journal = "Seminars in oncology nursing",

issn = "0749-2081",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Chemoprevention of human skin cancers

AU - Loescher, Lois J.

AU - Meyskens, Frank L.

N1 - Funding Information: In humans, oral DFMO has resulted in severe dose-related toxicities (gastrointestinal, neurologic, and hematologic toxicities, fatigue, rash, arthralgias, alopecia, high frequency hearing loss), necessitating discontinuation of the drug.5’ It has also been known to cause teratogenesis and induce abortions in animals. Little is known about the toxicity of topical DFMO, but when administered to UVB-irradiated mice, the toxicity of topical DFMO was minimal (personal communication, H. Gensler, February 1990). A chemoprevention trial funded by the National Cancer Institute is underway at the University of Arizona Cancer Center using topical DFMO and vitamin E in human subjects with actinic keratoses.

PY - 1991/2

Y1 - 1991/2

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U2 - 10.1016/0749-2081(91)90054-S

DO - 10.1016/0749-2081(91)90054-S

M3 - Article

C2 - 2011658

AN - SCOPUS:0026109685

SN - 0749-2081

VL - 7

SP - 45

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JO - Seminars in oncology nursing

JF - Seminars in oncology nursing

IS - 1

ER -

Chemoprevention of human skin cancers

ASJC Scopus subject areas

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