TY - JOUR
T1 - Chemical characterization of murine Ia alloantigens determined by the I-E/I-C subregions of the H-2 complex
AU - Silver, J.
AU - Russell, W. A.
AU - Reis, B. L.
AU - Frelinger, J. A.
PY - 1977
Y1 - 1977
N2 - Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.
AB - Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.
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U2 - 10.1073/pnas.74.11.5131
DO - 10.1073/pnas.74.11.5131
M3 - Article
C2 - 270749
AN - SCOPUS:0017698347
SN - 0027-8424
VL - 74
SP - 5131
EP - 5134
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11
ER -