Characterizing causality in cancer

Elena Rondeau; Thomas Pradeu; Andreas Bikfalvi; Nicolas Larmonier

doi:10.7554/eLife.53755

Characterizing causality in cancer

Elena Rondeau
, Thomas Pradeu
, Andreas Bikfalvi
, Nicolas Larmonier

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

Original language	English (US)
Article number	e53755
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.53755
State	Published - Nov 2019

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.7554/eLife.53755

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title = "Characterizing causality in cancer",

abstract = "Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.",

author = "Elena Rondeau and Thomas Pradeu and Andreas Bikfalvi and Nicolas Larmonier",

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AU - Rondeau, Elena

AU - Pradeu, Thomas

AU - Bikfalvi, Andreas

AU - Larmonier, Nicolas

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AB - Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

UR - https://www.scopus.com/pages/publications/85075781680

UR - https://www.scopus.com/pages/publications/85075781680#tab=citedBy

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SN - 2050-084X

VL - 8

JO - eLife

JF - eLife

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Characterizing causality in cancer

Abstract

ASJC Scopus subject areas

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