Characterizing causality in cancer

Elena Rondeau; Thomas Pradeu; Andreas Bikfalvi; Nicolas Larmonier

doi:10.7554/eLife.53755

Characterizing causality in cancer

Elena Rondeau, Thomas Pradeu, Andreas Bikfalvi, Nicolas Larmonier

Children's Research, Center of

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

Original language	English (US)
Article number	e53755
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.53755
State	Published - Nov 2019

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.7554/eLife.53755

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title = "Characterizing causality in cancer",

abstract = "Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.",

author = "Elena Rondeau and Thomas Pradeu and Andreas Bikfalvi and Nicolas Larmonier",

note = "Funding Information: We thank Doroth{\'e}e Duluc, Lucie Laplane, Ma{\"e}l Lemoine and Jean-Franc¸ ois Moreau for discussions. TP is funded by the European Research Council (IDEM: Grant agreement ID: 637647). AB is funded by the Ligue National du Cancer, the Association for Cancer Research, the National Cancer Institute, INSERM (the Plan Cancer) and SIRIC (the COMMUCAN project). NL is funded by the Ligue Nationale du Cancer. Publisher Copyright: {\textcopyright} 2019, eLife Sciences Publications Ltd. All rights reserved.",

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T1 - Characterizing causality in cancer

AU - Rondeau, Elena

AU - Pradeu, Thomas

AU - Bikfalvi, Andreas

AU - Larmonier, Nicolas

N1 - Funding Information: We thank Dorothée Duluc, Lucie Laplane, Maël Lemoine and Jean-Franc¸ ois Moreau for discussions. TP is funded by the European Research Council (IDEM: Grant agreement ID: 637647). AB is funded by the Ligue National du Cancer, the Association for Cancer Research, the National Cancer Institute, INSERM (the Plan Cancer) and SIRIC (the COMMUCAN project). NL is funded by the Ligue Nationale du Cancer. Publisher Copyright: © 2019, eLife Sciences Publications Ltd. All rights reserved.

PY - 2019/11

Y1 - 2019/11

N2 - Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

AB - Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

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Characterizing causality in cancer

Abstract

ASJC Scopus subject areas

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