Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration, and virologic end points

Hulin Wu, Daniel R. Kuritzkes, Daniel R. McClernon, Harold Kessler, Elizabeth Connick, Alan Landay, Greg Spear, Margo Heath-Chiozzi, Franck Rousseau, Lawrence Fox, John Spritzler, John M. Leonard, Michael M. Lederman

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine. Estimated first- and second-phase decay rates were d1 as 0.47/day and d2 as 0.04/day. Interpatient differences in both decay rates were significant. The d1 was directly correlated with baseline CD4+, CD4+CD28+, and CD8+CD28+ T lymphocyte counts (P< .05) and inversely correlated with baseline virus load (P = .044) and the magnitude of CD4+ and CD8+ T lymphocyte recovery (P<.01). The d2 was directly correlated with baseline percentage of CD8+ T lymphocytes (P = .023), the CD8+CD38+ cell number (P = .024), and the level of IgG that binds to human immunodeficiency virus (HIV) type 1 gp120 (P = .02). Vital decay rates were not predictive of treatment failure or durability of viral suppression. These exploratory findings are consistent with a model in which immunologic factors contribute to elimination of HIV-infected cells and suggest a dynamic interplay between regulation of HIV expression and lymphocyte activation and recovery.

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalJournal of Infectious Diseases
Volume179
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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