Enhanced production of prostaglandins (PG) by experimentally-induced and naturally occurring tumours and their effect on tumour growth and immunosurveillance have been noted. Directed toward further evaluation of the relationship between prostatic tumour growth and its milieu, i.e. its microenvironment, the possible correlation between levels of PG, tumour size and metastatic potential was investigated. For this purpose, the levels of PGE2 and PGF(2α) in peritumoural exudates of 3 tumour sublines of the Dunning R-3327 rat prostate adenocarcinoma: i) R-3327 Mat Lylu - fast growing and highly metastatic; ii) R-3327G - fast growing and poorly metastatic and iii) R-3327H - slow growing and poorly metastatic, were measured. The level of PGF(2α) was highly variable with no significant difference being noted between the tumour sublines. The mean values of PGF(2α) were, however, higher in the smaller tumours within each of the sublines. The levels of PGE2 were considerably higher in Mat Lylu exudates than those from the non-metastasing R-3327G and H sublines. A vasodilator and regulator of immunological responsiveness, PGE2 may function as a modulator of tumour metastases. In comsonance with studies by others, elevated levels of PGE2 may possibly serve as a prognostic marker for the high metastatic potential of neoplastic cells.
|Number of pages
|IRCS Medical Science
|Published - 1984
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology