Characterization of the Interaction between Viruses and a Solid Polymeric Contact Disinfectant

The interaction between three different viruses and a sparingly soluble polymeric contact disinfectant was characterized under a variety of conditions. It was found that pH, turbidity, resin concentration, temperature and type of virus determined the degree of Virus adsorption onto Resin 14 (a chloromethylated crosslinked polystyrene aminated with N,N dimethyl-tetradecylbenzyl). Numerous methods were evaluated to recover the adsorbed viruses. However, only a small percentage of the total virus adsorbed could be recovered, as determined by infectivity and radioactively labeled virus. While viruses are effectively retained by the resin, there was no evidence that they were inactivated. The recovery of infectious particles after the elution of viruses, which had adsorbed onto Resin 14, suggests that viral inactivation on the resin surface is not significant.