Characterization of responding cells in oxidative mitogen stimulation - III. Presence of I-A- and I-J, E, C-subregion gene products on the surface of required cells

M. Laurie Phillips; Sharon W. Hill; John W. Parker; Richard L. O'Brien; Jeffrey A. Frelinger

doi:10.1007/BF01561562

Characterization of responding cells in oxidative mitogen stimulation - III. Presence of I-A- and I-J, E, C-subregion gene products on the surface of required cells

M. Laurie Phillips, Sharon W. Hill, John W. Parker, Richard L. O'Brien, Jeffrey A. Frelinger

Immunobiology

Research output: Contribution to journal › Article › peer-review

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Abstract

Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded (or determined) by the I-A and I-J, E, C subregions of the Ir region can be detected on the surface of cells required for the response. In addition, I-A-subregion products have a functional significance in cellular activation which can be demonstrated by blocking experiments with anti-la serum in the absence of complement.

Original language	English (US)
Pages (from-to)	133-140
Number of pages	8
Journal	Immunogenetics
Volume	10
Issue number	1-4
DOIs	https://doi.org/10.1007/BF01561562
State	Published - Feb 1980

ASJC Scopus subject areas

Immunology
Genetics

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title = "Characterization of responding cells in oxidative mitogen stimulation - III. Presence of I-A- and I-J, E, C-subregion gene products on the surface of required cells",

abstract = "Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded (or determined) by the I-A and I-J, E, C subregions of the Ir region can be detected on the surface of cells required for the response. In addition, I-A-subregion products have a functional significance in cellular activation which can be demonstrated by blocking experiments with anti-la serum in the absence of complement.",

author = "Phillips, {M. Laurie} and Hill, {Sharon W.} and Parker, {John W.} and O'Brien, {Richard L.} and Frelinger, {Jeffrey A.}",

year = "1980",

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AU - Parker, John W.

AU - O'Brien, Richard L.

AU - Frelinger, Jeffrey A.

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AB - Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded (or determined) by the I-A and I-J, E, C subregions of the Ir region can be detected on the surface of cells required for the response. In addition, I-A-subregion products have a functional significance in cellular activation which can be demonstrated by blocking experiments with anti-la serum in the absence of complement.

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Characterization of responding cells in oxidative mitogen stimulation - III. Presence of I-A- and I-J, E, C-subregion gene products on the surface of required cells

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