Characterization of High-Salt and High-Fat Diets on Cardiac and Vascular Function in Mice

Qianli Yu, Douglas F. Larson, Denise Slayback, Tamara F. Lundeen, Jeffrey H. Baxter, Ronald R. Watson

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


This study compared two established dietary formulations, high salt and high fat-high carbohydrate, separately or in combination on the induction cardiovascular dysfunction. One-month-old C57BL/6J mice were fed one of the following diets for 3 mo: (1) control diet consisting of a high fat-high simple carbohydrate (HFHSC); (2) 8% NaCl diet (HS); or (3) HFHSC diet supplemented with 1% NaCl (HFHS). After 3 mo, the HFHSC mice demonstrated significantly increased end-diastolic volume and end-systolic volume, specifically increases of 35% and 78%, respectively (p < 0.01) and a reduction of ventricular stiffness by 27% (p = 0.015). The HS mice exhibited arterial hypertension with an increase of 33% in maximum end-systolic pressure (p = .024) and a decrease of 44% in arterial elastance (p = 0.020), corroborated by an increase in the heart weight to body weight ratios (p = 0.002) and vascular types I and III collagen (p = 0.03 and p = 0.0008, respectively). The HFHS group revealed a striking response of 230% to the α1-adrenergic challenge (p = 0.00034). These data suggest that the HFHSC diet causes dilated cardiomyopathy, whereas the HS diet produces arterial hypertension and the HFHS diet causes a vascular dysfunctional state that was highly responsive to α-adrenergic stimulation.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalCardiovascular toxicology
Issue number1
StatePublished - 2004


  • C57BL/6
  • Cardiomyopathy
  • Conductance catheter
  • Heart function
  • Hypertension
  • Sodium chloride intake
  • Vascular function

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine


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