TY - CHAP
T1 - Chapter 16 Glucagon
T2 - Molecular biology and structure-activity
AU - Hruby, Victor J.
N1 - Funding Information:
The partial support of the U. S. Public Health Service Grant DK-21085 is gratefully acknowledged. I am particularly grateful for the outstanding collaborations of the excellent undergraduate and graduate students, postdoctoral associates, and fellow colleagues who have worked with me in our studies. The contents of this paper are solely the responsibility of the author and do not necessarily represent the views of the USPHS.
PY - 1998
Y1 - 1998
N2 - The actions of glucagon at hepatic and fat cell receptors is critical for the control of glucose levels and glucose homeostasis in normal and diabetic states. Its interactions with insulin in maintaining homeostasis in normal animals is understood in considerable detail and tools are now available to obtain an even deeper understanding. In the diabetic state, the interplay of glucagon and insulin (and other factors) in hyperglycemia, ketoses, and other manifestations of diabetes is less clear, and provides a continuing challenge for biochemists, physiologists, endocrinologists, and molecular biologists. Fortunately, new tools in the form of potent receptor agonists and antagonists, cloned receptors, assays with enhanced sensitivity, and increased understanding of receptor transduction mechanism should greatly aid in obtaining these needed new insights and understanding.
AB - The actions of glucagon at hepatic and fat cell receptors is critical for the control of glucose levels and glucose homeostasis in normal and diabetic states. Its interactions with insulin in maintaining homeostasis in normal animals is understood in considerable detail and tools are now available to obtain an even deeper understanding. In the diabetic state, the interplay of glucagon and insulin (and other factors) in hyperglycemia, ketoses, and other manifestations of diabetes is less clear, and provides a continuing challenge for biochemists, physiologists, endocrinologists, and molecular biologists. Fortunately, new tools in the form of potent receptor agonists and antagonists, cloned receptors, assays with enhanced sensitivity, and increased understanding of receptor transduction mechanism should greatly aid in obtaining these needed new insights and understanding.
UR - https://www.scopus.com/pages/publications/77957064035
UR - https://www.scopus.com/inward/citedby.url?scp=77957064035&partnerID=8YFLogxK
U2 - 10.1016/S1569-2582(97)80161-4
DO - 10.1016/S1569-2582(97)80161-4
M3 - Chapter
AN - SCOPUS:77957064035
T3 - Principles of Medical Biology
SP - 387
EP - 401
BT - Principles of Medical Biology
PB - Elsevier Inc.
ER -