Changes in speckle-tracking-derived mechanical dispersion index are associated with 30-day readmissions in acute heart failure

Background: The objective of the present study was to evaluate the relationship between speckle-tracking-derived parameters left ventricular (LV) mechanical dispersion index (MDI), defined as the standard deviation of the timeto-peak longitudinal strain of all segments analyzed of the LV, and global longitudinal strain (GLS) and 30-day postdischarge outcomes (death and readmission to the hospital) in patients with acute heart failure (AHF). Methods: We performed a prospective observational study of selected emergency department patients with a primary diagnosis of AHF. Point-of-care echocardiograms were performed at baseline (prior to, or concurrent with the initiation of treatment) and 23 h post-enrollment. Offline speckle-tracking analysis was utilized to calculate GLS and MDI. The primary outcome was 30-day readmissions. Results: A total of 31 patients were included, 13 of whom were readmitted within 30 days. Patients who were not readmitted to the hospital experienced an average relative improvement in MDI of 24% from baseline to 23 h (84 ms to 64 ms), while patients who were readmitted experienced an average relative worsening in MDI of 6% (66 ms to 70 ms) from baseline to 23 h. Conclusions: MDI has promise as a treatment response variable in admitted patients with AHF; however, further study is needed.