Abstract
A variety of mechanisms have been proposed to explain how tumors evade immune destruction. This work has identified one such mechanism that determines susceptibility to immune lysis; membrane phospholipid composition altered susceptibility to antibody plus complement (Ab. +. C)-mediated lysis. Effects on antibody plus complement-mediated lysis were correlated with levels of major histocompatibility complex (MHC) molecules but not inherent resistance to complement damage. This cellular mechanism could be a means by which tumor cells escape immune detection and destruction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 231-236 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 417 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 6 2012 |
Keywords
- Antibody
- Complement
- Cytolysis
- Phospholipids
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology