Changes in plasma membrane phospholipids inhibit antibody-mediated lysis

David T. Harris

doi:10.1016/j.bbrc.2011.11.090

Changes in plasma membrane phospholipids inhibit antibody-mediated lysis

David T. Harris

Immunobiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A variety of mechanisms have been proposed to explain how tumors evade immune destruction. This work has identified one such mechanism that determines susceptibility to immune lysis; membrane phospholipid composition altered susceptibility to antibody plus complement (Ab. +. C)-mediated lysis. Effects on antibody plus complement-mediated lysis were correlated with levels of major histocompatibility complex (MHC) molecules but not inherent resistance to complement damage. This cellular mechanism could be a means by which tumor cells escape immune detection and destruction.

Original language	English (US)
Pages (from-to)	231-236
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	417
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2011.11.090
State	Published - Jan 6 2012

Keywords

Antibody
Complement
Cytolysis
Phospholipids

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2011.11.090

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KW - Cytolysis

KW - Phospholipids

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Changes in plasma membrane phospholipids inhibit antibody-mediated lysis

Abstract

Keywords

ASJC Scopus subject areas

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