TY - JOUR
T1 - Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs. reduced carbohydrate diets
AU - Thomson, Cynthia A.
AU - Stopeck, Alison T.
AU - Bea, Jennifer W.
AU - Cussler, Ellen
AU - Nardi, Emily
AU - Frey, Georgette
AU - Thompson, Patricia A.
N1 - Funding Information:
This work was completed at the Arizona Cancer Center and University of Arizona Department of Nutritional Sciences, Tucson, Arizona. This research was funded by the Robert C. and Veronica Atkins Foundation, the University of Arizona Cancer Center R25T CA-78447and P30-CA23074. The authors would like to thank the breast cancer survivors who participated in this trial, as well as phlebotomy support provided by Kelly Morrow, support for randomization provided by Steve Rodney at the Arizona Cancer Center, and support for diet and physical activity assessment provided by the Behavioral Measurements Shared Service under the direction of Lynn Hamilton.
PY - 2010/11
Y1 - 2010/11
N2 - Overweight status is common among women breast cancer survivors and places them at greater risk for metabolic disorders, cardiovascular morbidity, and breast cancer recurrence than nonoverweight survivors. Efforts to promote weight control in this population are needed. The objective of this research was to evaluate the effect of low-fat or low-carbohydrate diet counseling on weight loss, body composition, and changes in metabolic indexes in overweight postmenopausal breast cancer survivors. Survivors (n = 40) were randomized to receive dietitian counseling for a low-fat or a reduced carbohydrate diet for 6 mo. Weight and metabolic measures, including glucose, insulin, HbA1c, HOMA, lipids, hsCRP, as well as blood pressure were measured at baseline, 6, 12 and 24 wk. Dietary intake of fat and carbohydrate was reduced by 24 and 76g/day, respectively. Weight loss averaged 6.1 (± 4.8 kg) at 24 wk and was not significantly different by diet group; loss of lean mass was also demonstrated. All subjects demonstrated improvements in total/HDL cholesterol ratio, and significant reductions in HbA1c, insulin, and HOMA. Triglycerides levels were significantly reduced only in the low-carbohydrate diet group (-31.1 ± 36.6; P = 0.01). Significant improvements in weight and metabolic indexes can be demonstrated among overweight breast cancer survivors adherent to either a carbohydrate- or fat-restricted diet.
AB - Overweight status is common among women breast cancer survivors and places them at greater risk for metabolic disorders, cardiovascular morbidity, and breast cancer recurrence than nonoverweight survivors. Efforts to promote weight control in this population are needed. The objective of this research was to evaluate the effect of low-fat or low-carbohydrate diet counseling on weight loss, body composition, and changes in metabolic indexes in overweight postmenopausal breast cancer survivors. Survivors (n = 40) were randomized to receive dietitian counseling for a low-fat or a reduced carbohydrate diet for 6 mo. Weight and metabolic measures, including glucose, insulin, HbA1c, HOMA, lipids, hsCRP, as well as blood pressure were measured at baseline, 6, 12 and 24 wk. Dietary intake of fat and carbohydrate was reduced by 24 and 76g/day, respectively. Weight loss averaged 6.1 (± 4.8 kg) at 24 wk and was not significantly different by diet group; loss of lean mass was also demonstrated. All subjects demonstrated improvements in total/HDL cholesterol ratio, and significant reductions in HbA1c, insulin, and HOMA. Triglycerides levels were significantly reduced only in the low-carbohydrate diet group (-31.1 ± 36.6; P = 0.01). Significant improvements in weight and metabolic indexes can be demonstrated among overweight breast cancer survivors adherent to either a carbohydrate- or fat-restricted diet.
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U2 - 10.1080/01635581.2010.513803
DO - 10.1080/01635581.2010.513803
M3 - Article
C2 - 21058203
AN - SCOPUS:78249239785
SN - 0163-5581
VL - 62
SP - 1142
EP - 1152
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 8
ER -