Chagas Disease in Pregnant Women from Endemic Regions Attending the Hospital General de Mexico, Mexico City

Indira Chakravarti, Monica Miranda-Schaeubinger, Adriana Ruiz-Remigio, Carlos Briones-Garduño, Edith A. Fernández-Figueroa, Concepción Celeste Villanueva-Cabello, Alejandra Borge-Villareal, Yadira Bejar-Ramírez, Alejandro Pérez-González, César Rivera-Benitez, Eyal Oren, Heidi E. Brown, Ingeborg Becker, Robert H. Gilman

Research output: Contribution to journalArticlepeer-review

Abstract

Trypanosoma cruzi infection leads to Chagas disease (CD), a neglected tropical infection of significant public health importance in South and Central America and other, non-endemic, countries. Pregnant women and their children are of particular importance to screen as T. cruzi can be transmitted vertically. The objective of this study was to screen for T. cruzi infection among pregnant women from endemic areas seen at the Hospital General de Mexico for prenatal care, so that they and their children may be quickly connected to CD treatment. Pregnant women were recruited through the hospital prenatal clinic and screened for T. cruzi infection using a series of serological and molecular tests. Of 150 screened patients, mean age 26.8 (SD 6.4), 30 (20.0%) were positive by at least one diagnostic test. Of these, only nine (6%) were positive as determined by PCR. Diagnosis of chronic CD is difficult in endemic places like Mexico due to the limitations of current commercially available diagnostic tests. Further evaluation of diagnostic performance of various assays could improve current CD diagnostic algorithms and proper care management in these regions. Genetic variability in the parasite may also play a role in the differing assay performances seen in this study, and this may be a valuable avenue of further research.

Original languageEnglish (US)
Article number8
JournalTropical Medicine and Infectious Disease
Volume7
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Chagas disease
  • Chagas disease diagnosis
  • Congenital Chagas disease
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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