Alzheimer's disease is associated with reductions in resting-state brain metabolism, as measured by PET, progressing with dementia severity. The purpose of this study was to see to what extent brain regions with reduced resting-state metabolic rates in Alzheimer patients could be activated by a passive audiovisual stimulation test and to compare the result with activation in age-matched healthy volunteers. The extent of activation in Alzheimer's disease is considered to reflect the integrity of synaptic function, or inherent viability, and the potential responsiveness of the Alzheimer brain to drug therapy. Methods: Regional cerebral metabolic rates for glucose (rCMR(gic), in mg/100 g tissue/min) were measured in the resting state (eyes and ears covered) and during passive audiovisual stimulation (watching a movie) in 15 otherwise healthy Alzheimer patients of differing dementia severity (Mattis Dementia Rating Scale score, 23-128) and in 14 age- matched healthy volunteers (score, 141 ± 3) using PET with 2 sequential injections of FDG. Results: In the volunteers, audiovisual stimulation caused significant rCMR(glc) increases in visual and auditory cortical areas but significant decreases in frontal areas. In the mildly demented patients, rCMR(glc) responses were within 2 SDs of the mean in volunteers. However, the magnitude of the rCMR(glc) responses during stimulation declined significantly with dementia severity in the right occipitotemporal, right and left occipital association, and left calcarine cortical regions. Conclusion: Functional brain responsiveness, evaluated by a passive audiovisual stimulation paradigm with PET, is within normal limits in mildly demented Alzheimer patients but fails with worsening dementia severity. Declining responsiveness may account for the limited success of neurotransmitter replacement therapy in Alzheimer patients with moderate-to-severe dementia.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Nuclear Medicine|
|State||Published - Apr 2000|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging